| C & C Exterminators, Inc. | Administrative and Support and Waste Management | $62,800 | $63,232 | 9 | <$5M |  Research |
| Merchney LLC | Manufacturing | $61,298 | $62,064 | 7 | <$5M | Research |
| Pickens County Meals On Wheels INC DBA | Health Care and Social Assistance | $59,880 | $60,624 | 8 | N/A | Research |
| Gallamore Seamless Gutters, Inc. | Wholesale Trade | $58,588 | $59,011 | 10 | <$5M | Research |
| Am Mechanical INC | Construction | $55,117 | $55,504 | 5 | <$5M | Research |
| Bottom Line Military Sales LLC | Wholesale Trade | $55,000 | $55,344 | 12 | <$5M | Research |
| Barker Search LLC | Administrative and Support and Waste Management | $54,450 | $54,681 | 2 | <$5M | Research |
| Danyels Turf INC | Administrative and Support and Waste Management | $52,636 | $44,625 | 7 | <$5M | Research |
| Gallamore Seamless Gutters Inc. | Construction | $52,366 | $52,639 | 9 | <$5M | Research |
| Seth Crow Agency LLC | Finance and Insurance | $51,200 | $51,691 | 5 | <$5M | Research |
| Gillespie Construction Co. Inc. | Construction | $49,500 | $49,705 | 6 | <$5M | Research |
| Machining Solutions & Fabrication | Manufacturing | $46,927 | $47,215 | 4 | <$5M | Research |
| Trinity Family Practice, LLC | Health Care and Social Assistance | $46,740 | $47,116 | 7 | <$5M | Research |
| Jet Electrical LLC | Construction | $45,135 | $0 | 10 | <$5M | Research |
| Bushey Enterprises INC | Unknown | $44,702 | $45,186 | 5 | N/A | Research |
| Palmetto Upstate Group LLC | Professional, Scientific, and Technical Services | $42,778 | $43,259 | 7 | <$5M | Research |
| Dynamic Installations INC | Transportation and Warehousing | $41,042 | $41,419 | 11 | <$5M | Research |
| Barker Search LLC | Administrative and Support and Waste Management | $40,682 | $40,962 | 3 | <$5M | Research |
| Pg Aerospace LLC | Manufacturing | $40,600 | $40,945 | 5 | <$5M | Research |
| Pickens County Humane Society | Other Services (except Public Administration) | $39,500 | $39,960 | 4 | <$5M | Research |
| Playhouse Pals of the Carolina Corp | Health Care and Social Assistance | $38,500 | $38,878 | 14 | <$5M | Research |
| Qsb Technologies INC | Health Care and Social Assistance | $37,900 | $38,284 | 9 | <$5M | Research |
| Innovative Masonry Enterprises LLC | Construction | $37,700 | $38,149 | 6 | <$5M | Research |
| Majestic Staircases Inc. | Retail Trade | $37,600 | $37,790 | 6 | <$5M | Research |
| Liberty Bell LLC | Accommodation and Food Services | $33,582 | $33,801 | 7 | <$5M | Research |