| Clarendon County Disabilities & Special Needs Board | Health Care and Social Assistance | $1,039,107 | $1,051,230 | 193 | N/A |  Research |
| Laurence Manning Academy | Educational Services | $508,638 | $512,163 | 92 | N/A | Research |
| Prothro Chevrolet Co. Inc. | Retail Trade | $381,219 | $384,749 | 30 | $7.6M | Research |
| Santee Automotive LLC | Other Services (except Public Administration) | $363,645 | $368,059 | 43 | $8.4M | Research |
| Alucoil North Americia, LLC | Management of Companies and Enterprises | $242,288 | $244,790 | 26 | <$5M | Research |
| Advanta Southeast LLC | Manufacturing | $219,114 | $221,713 | 18 | <$5M | Research |
| Advanta Southeast, LLC | Manufacturing | $219,100 | $220,774 | 20 | $5.6M | Research |
| Land Parker Welch LLC | Professional, Scientific, and Technical Services | $213,707 | $215,749 | 14 | <$5M | Research |
| Clarks Transport Co., LLC | Transportation and Warehousing | $186,958 | $188,750 | 17 | <$5M | Research |
| Atc Home Health Care, Llc. | Health Care and Social Assistance | $170,222 | $171,663 | 85 | $14.6M | Research |
| Santee Pole & Piling Inc. | Agriculture, Forestry, Fishing and Hunting | $165,200 | $166,888 | 13 | <$5M | Research |
| Southern Lakes Therapy LLC | Health Care and Social Assistance | $138,367 | $139,167 | 17 | <$5M | Research |
| Clarendon County Commision On Alcohol and Drug Abuse | Health Care and Social Assistance | $125,869 | $126,946 | 12 | N/A | Research |
| Clarendon County Commission On Alcohol and Drug Abuse | Health Care and Social Assistance | $120,354 | $121,003 | 11 | N/A | Research |
| Carolina Tree Care LLC | Administrative and Support and Waste Management | $118,982 | $119,643 | 14 | <$5M | Research |
| Southeastern Games, LLC | Arts, Entertainment, and Recreation | $117,800 | $118,972 | 15 | <$5M | Research |
| Hotel Ventures of Manning INC | Accommodation and Food Services | $107,933 | $108,701 | 25 | $7.8M | Research |
| Mill Street Drugs, INC | Wholesale Trade | $103,774 | $104,653 | 8 | <$5M | Research |
| 2-Way Transportation LLC | Transportation and Warehousing | $102,636 | $103,552 | 60 | <$5M | Research |
| 2 Way Transportation LLC | Transportation and Warehousing | $102,636 | $102,951 | 40 | <$5M | Research |
| M&m Enterprises, LLC | Manufacturing | $93,880 | $94,641 | 8 | <$5M | Research |
| Carolina Tree Care, LLC | Administrative and Support and Waste Management | $92,597 | $93,402 | 15 | <$5M | Research |
| Mid Eastern Truck Wash, Inc. | Other Services (except Public Administration) | $91,400 | $91,989 | 32 | $6.3M | Research |
| Manning Dental Associates, PA | Health Care and Social Assistance | $88,136 | $88,910 | 9 | <$5M | Research |
| Brunson's Pharmacy, LLC | Health Care and Social Assistance | $86,371 | $87,079 | 9 | <$5M | Research |