| Foothills Machining, Inc. | Manufacturing | $310,000 | $312,282 | 26 | $6.4M |  Research |
| Durham's Hardwood of Pickens INC | Manufacturing | $306,099 | $307,808 | 50 | $49.6M | Research |
| Behavioral Health Services of Pickens County | Health Care and Social Assistance | $304,161 | $306,003 | 49 | N/A | Research |
| Pickens County Commission On Alcohol and Drug Abuse | Health Care and Social Assistance | $304,161 | $305,437 | 49 | N/A | Research |
| Lindsay Oil Company INC | Wholesale Trade | $251,925 | $253,761 | 24 | $6.2M | Research |
| Lindsay Oil Company | Wholesale Trade | $232,708 | $235,889 | 22 | $5.7M | Research |
| Great Oaks Dental P.a. | Health Care and Social Assistance | $217,700 | $218,867 | 20 | <$5M | Research |
| Rek Inc. | Finance and Insurance | $192,232 | $193,102 | 15 | $6.6M | Research |
| Rek, Inc. | Transportation and Warehousing | $179,168 | $180,626 | 15 | <$5M | Research |
| Gar-Con, INC | Construction | $167,858 | $144,849 | 13 | <$5M | Research |
| Foothills Mechanical, INC | Construction | $167,500 | $168,744 | 23 | $7.3M | Research |
| Harris Automotive Recon INC | Other Services (except Public Administration) | $160,500 | $161,406 | 20 | <$5M | Research |
| Foothills Mechanical INC | Construction | $149,800 | $150,662 | 18 | $5.7M | Research |
| Pickens Dental Associates PA | Health Care and Social Assistance | $145,400 | $147,129 | 16 | <$5M | Research |
| Crenshaw Asphalt Paving, Inc. | Construction | $142,120 | $144,062 | 15 | <$5M | Research |
| Pickens Dental Associates P.a. | Health Care and Social Assistance | $142,000 | $143,163 | 17 | <$5M | Research |
| Pickens Animal Hospital, P.a. | Professional, Scientific, and Technical Services | $128,015 | $129,256 | 27 | <$5M | Research |
| Acker Lambert Hinton P.a. | Professional, Scientific, and Technical Services | $109,173 | $110,113 | 9 | <$5M | Research |
| Chicken Pickin' INC | Accommodation and Food Services | $104,300 | $105,023 | 28 | <$5M | Research |
| Jamieson Grading INC | Construction | $95,854 | $96,757 | 9 | <$5M | Research |
| Underdog Express INC | Transportation and Warehousing | $89,690 | $90,056 | 10 | <$5M | Research |
| Underdog Express, Inc. | Transportation and Warehousing | $89,690 | $90,355 | 13 | <$5M | Research |
| S C Dunn and Sons INC | Manufacturing | $86,626 | $87,656 | 10 | $9.9M | Research |
| Moral of Pickens, Inc. | Retail Trade | $86,468 | $87,692 | 8 | <$5M | Research |
| Cassell & Hendricks CPA PA | Professional, Scientific, and Technical Services | $85,540 | $76,669 | 7 | <$5M | Research |