| The Blood Connection Inc. | Other Services (except Public Administration) | $3,415,300 | $3,455,145 | 430 | N/A |  Research |
| First Sun Management Corporation | Accommodation and Food Services | $1,890,200 | $1,904,597 | 500 | $88.8M | Research |
| Oppermann Webbing INC | Manufacturing | $1,889,194 | $1,914,750 | 200 | $70.6M | Research |
| Kudzu Staffing Inc. | Administrative and Support and Waste Management | $1,884,500 | $1,909,128 | 500 | $78.7M | Research |
| Lesley Holding Company Inc. | Manufacturing | $1,455,350 | $1,464,648 | 100 | $24.4M | Research |
| Lesley Holding Company, Inc. | Manufacturing | $1,437,142 | $1,449,955 | 132 | $32.3M | Research |
| Owen Brothers, INC | Manufacturing | $1,399,800 | $1,411,650 | 132 | $130.9M | Research |
| Ray Walker Trucking Company, Inc. | Transportation and Warehousing | $1,066,210 | $1,074,185 | 109 | $16.5M | Research |
| Carolina Heating Services, Inc. of Greenville | Construction | $1,000,000 | $962,609 | 68 | $21.5M | Research |
| Kudzu Staffing of Columbia Inc. | Administrative and Support and Waste Management | $826,700 | $837,255 | 150 | $23.6M | Research |
| Arnold's of Piedmont | Accommodation and Food Services | $776,900 | $65,418 | 5 | <$5M | Research |
| Vital Care Ems, Inc. | Health Care and Social Assistance | $750,990 | $758,396 | 139 | $32.2M | Research |
| No-Fade Coatings, Inc. | Wholesale Trade | $745,700 | $751,053 | 57 | $17.5M | Research |
| Matica Corp | Wholesale Trade | $657,340 | $667,072 | 37 | $11.3M | Research |
| Arc Labs LLC | Educational Services | $654,832 | $658,743 | 61 | $12.8M | Research |
| Kudzu Staffing of Charleston Inc. | Administrative and Support and Waste Management | $613,000 | $620,793 | 150 | $23.6M | Research |
| Arclabs, LLC | Educational Services | $610,242 | $614,238 | 47 | $9.9M | Research |
| Sherman Construction Co., Inc. | Construction | $595,437 | $599,043 | 26 | $29.6M | Research |
| Sparks Industrial Service, LLC | Administrative and Support and Waste Management | $559,528 | $565,294 | 35 | $6.6M | Research |
| Sparks Industrial Service LLC | Transportation and Warehousing | $559,525 | $565,742 | 59 | $15.8M | Research |
| Smokin Pig INC | Accommodation and Food Services | $498,000 | $503,658 | 127 | $22.5M | Research |
| Sherman Construction Co INC | Construction | $471,064 | $474,545 | 28 | $31.9M | Research |
| Bennett Equipment & Supply Co., LLC | Wholesale Trade | $463,200 | $467,163 | 38 | $11.6M | Research |
| Kinard-Stone INC | Professional, Scientific, and Technical Services | $453,400 | $459,332 | 24 | <$5M | Research |
| Yeargin Miscellaneous Metals, INC | Manufacturing | $437,500 | $441,360 | 37 | $9.7M | Research |