| Cliffs Club Services LLC | Accommodation and Food Services | $4,900,770 | $4,964,208 | 500 | $88.8M |  Research |
| Chestnut Hill Mental Health Center, Inc. | Health Care and Social Assistance | $2,389,182 | $2,416,525 | 305 | $60.5M | Research |
| Pivot Pizza Company LLC | Accommodation and Food Services | $884,082 | $889,629 | 125 | $22.2M | Research |
| Keith's Welding Service | Retail Trade | $750,000 | $755,712 | 50 | $7.8M | Research |
| Pivot Pizza Company LLC | Accommodation and Food Services | $746,800 | $750,940 | 173 | $30.7M | Research |
| George Coleman Motor Company, INC | Retail Trade | $517,100 | $520,375 | 43 | $10.8M | Research |
| Red Elm Residential & Landscapes, LLC | Administrative and Support and Waste Management | $427,000 | $429,598 | 41 | $8.9M | Research |
| Payne, Mcginn and Cummins, INC | Construction | $423,900 | $427,152 | 31 | $9.6M | Research |
| Look Up Lodge Christian Camp Inc. | Other Services (except Public Administration) | $375,062 | $377,508 | 26 | <$5M | Research |
| Look Up Lodge Christian Camp, INC | Accommodation and Food Services | $298,700 | $300,394 | 31 | $9.7M | Research |
| Borgeson Universal Company Inc. | Manufacturing | $284,200 | $285,847 | 25 | $6.5M | Research |
| Cleveland Park Animal Hospital of the Upstate, Inc. | Professional, Scientific, and Technical Services | $283,800 | $285,787 | 27 | <$5M | Research |
| North Greenville Fitness and Cardiac Rehabilitation Clinic I | Health Care and Social Assistance | $279,447 | $281,889 | 32 | $6.3M | Research |
| North Greenville Fitness and Cardiac Rehabilitation Clinic, | Health Care and Social Assistance | $278,700 | $280,536 | 36 | $7.1M | Research |
| T-Rest Hospitality LLC | Accommodation and Food Services | $270,806 | $272,942 | 46 | $14.4M | Research |
| Farmhouse Tacos LLC | Accommodation and Food Services | $270,100 | $273,104 | 31 | $5.5M | Research |
| Shortfields LLC | Accommodation and Food Services | $265,600 | $267,768 | 91 | $16.2M | Research |
| Advanced Fire Protection Inc. | Public Administration | $265,000 | $267,091 | 27 | N/A | Research |
| Samaritan Bed and Bath Service INC | Health Care and Social Assistance | $259,600 | $260,752 | 105 | $18.0M | Research |
| Samaritan Bed and Bath Service INC | Health Care and Social Assistance | $259,600 | $261,712 | 105 | $18.0M | Research |
| Advanced Fire Protection Inc. | Manufacturing | $250,787 | $252,855 | 24 | $6.3M | Research |
| Gabriel Builders, INC | Construction | $245,909 | $248,040 | 17 | $5.2M | Research |
| Greenville Dental Management Group PA | Health Care and Social Assistance | $224,370 | $226,036 | 16 | <$5M | Research |
| T-Rest Opco LLC | Accommodation and Food Services | $220,520 | $222,401 | 32 | $10.0M | Research |
| Holmes Underground Inc. | Construction | $220,260 | $222,197 | 22 | $6.8M | Research |