| Hampton Regional Medical Center | Health Care and Social Assistance | $2,251,622 | $2,277,346 | 182 | N/A | AI Deep Dive |
| Morning Star Home Care Services LLC | Health Care and Social Assistance | $189,037 | $191,326 | 45 | $7.7M | AI Deep Dive |
| Southern Metal Works Inc. | Manufacturing | $170,305 | $171,583 | 17 | <$5M | AI Deep Dive |
| Coastal Plains Physician Associates | Health Care and Social Assistance | $169,272 | $170,496 | 13 | N/A | AI Deep Dive |
| Southern Metal Works Inc. | Other Services (except Public Administration) | $167,335 | $168,619 | 17 | <$5M | AI Deep Dive |
| Low Country Family Services INC | Health Care and Social Assistance | $161,320 | $162,544 | 75 | $12.8M | AI Deep Dive |
| Coastal Technologies Inc. | Manufacturing | $159,049 | $160,494 | 9 | <$5M | AI Deep Dive |
| Hampton Dentistry LLC | Health Care and Social Assistance | $66,100 | $66,596 | 7 | <$5M | AI Deep Dive |
| Welch Forest Products LLC | Agriculture, Forestry, Fishing and Hunting | $65,302 | $66,107 | 7 | <$5M | AI Deep Dive |
| Hampton Dentistry, LLC | Health Care and Social Assistance | $64,947 | $65,317 | 7 | <$5M | AI Deep Dive |
| Gordon Forest Products, LLC | Agriculture, Forestry, Fishing and Hunting | $64,125 | $64,740 | 6 | <$5M | AI Deep Dive |
| Smiley & Sons, Inc. | Construction | $51,675 | $51,977 | 6 | <$5M | AI Deep Dive |
| Station, INC the | Other Services (except Public Administration) | $49,810 | $57,757 | 9 | <$5M | AI Deep Dive |
| Kak Enterprise LLC | Administrative and Support and Waste Management | $48,567 | $49,174 | 6 | <$5M | AI Deep Dive |
| John H. Stanley Jr. | Accommodation and Food Services | $44,835 | $45,204 | 10 | <$5M | AI Deep Dive |
| Carlene M. Cook | Accommodation and Food Services | $44,745 | $45,110 | 10 | <$5M | AI Deep Dive |
| Carlene M Cook | Accommodation and Food Services | $38,357 | $38,622 | 12 | <$5M | AI Deep Dive |
| Complete Air LLC | Construction | $37,720 | $37,966 | 4 | <$5M | AI Deep Dive |
| Griner Farms | Agriculture, Forestry, Fishing and Hunting | $37,240 | $37,684 | 5 | <$5M | AI Deep Dive |
| Kishan Khanaiya, INC | Retail Trade | $35,555 | $35,990 | 13 | <$5M | AI Deep Dive |
| Alexandria Cohen | Accommodation and Food Services | $29,166 | $29,219 | 1 | <$5M | AI Deep Dive |
| First Choice Transportation, LLC | Transportation and Warehousing | $25,030 | $25,300 | 5 | <$5M | AI Deep Dive |
| Timothy C. Minchey | Real Estate and Rental and Leasing | $21,066 | $21,217 | 2 | <$5M | AI Deep Dive |
| Smiths Handyman & Honey-Do, LLC | Other Services (except Public Administration) | $20,835 | $15,323 | 1 | <$5M | AI Deep Dive |
| Latarver Williams | Accommodation and Food Services | $20,833 | $20,868 | 1 | <$5M | AI Deep Dive |