| Element Tv Company, LP | Manufacturing | $1,818,030 | $1,781,454 | 216 | $56.6M |  Research |
| Winnsboro Petroleum Co | Wholesale Trade | $929,200 | $934,414 | 210 | $54.1M | Research |
| Fairfield County Disabilities and Special Needs Board | Health Care and Social Assistance | $843,127 | $742,830 | 198 | N/A | Research |
| Fairfield Medical Associates PA | Health Care and Social Assistance | $368,300 | $372,679 | 65 | $20.4M | Research |
| Wilson Chevrolet, Inc. | Retail Trade | $289,796 | $292,010 | 27 | $6.8M | Research |
| Wilson Chrysler Dodge Jeep, INC | Retail Trade | $281,088 | $283,235 | 21 | $5.3M | Research |
| Midlands Stem Institute | Professional, Scientific, and Technical Services | $263,887 | $266,929 | 30 | N/A | Research |
| Palmetto Imaging Technology LLC | Manufacturing | $218,623 | $219,959 | 25 | $7.0M | Research |
| Palmetto Imaging Technology, LLC | Manufacturing | $218,622 | $220,286 | 25 | $24.8M | Research |
| Green Energy Biofuel LLC | Manufacturing | $208,910 | $211,359 | 23 | $22.8M | Research |
| Precious Adult Daycare INC | Health Care and Social Assistance | $182,900 | $183,938 | 65 | $10.5M | Research |
| Cambio Academy Sc LLC | Educational Services | $181,603 | $182,606 | 41 | <$5M | Research |
| Cambio Academy Sc, LLC | Educational Services | $181,603 | $182,516 | 49 | $6.4M | Research |
| Cedar Creek Collision Inc. | Other Services (except Public Administration) | $144,300 | $145,925 | 14 | <$5M | Research |
| Fairfield Behavioral Health Service | Health Care and Social Assistance | $137,200 | $138,147 | 12 | <$5M | Research |
| Healthcare Sc LLC | Professional, Scientific, and Technical Services | $129,732 | $129,818 | 73 | $10.2M | Research |
| Carolina Adventure World LLC | Accommodation and Food Services | $123,000 | $123,622 | 25 | $7.8M | Research |
| Philip C. Wilkins, D.m.d., P.c. | Health Care and Social Assistance | $106,855 | $107,858 | 8 | <$5M | Research |
| Porter Gas Service, Inc. | Utilities | $105,473 | $106,410 | 8 | N/A | Research |
| Philip C Wilkins Dmd PC | Health Care and Social Assistance | $102,767 | $103,358 | 11 | <$5M | Research |
| Precision Equipment & Design | Manufacturing | $96,910 | $98,333 | 7 | <$5M | Research |
| Hazen Masonry LLC | Construction | $94,908 | $96,177 | 15 | <$5M | Research |
| The Community Health Foundation of Fairfield County | Health Care and Social Assistance | $90,700 | $91,485 | 16 | N/A | Research |
| W. H. Owens Inc. | Transportation and Warehousing | $86,900 | $87,412 | 11 | <$5M | Research |
| W. H. Owens Inc. | Transportation and Warehousing | $85,900 | $86,389 | 8 | <$5M | Research |