| Crowns Now Dental Holding LLC | Health Care and Social Assistance | $855,200 | $860,236 | 68 | $15.8M |  Research |
| A Grade Above Others | Construction | $633,527 | $636,941 | 63 | $19.5M | Research |
| A Grade Above Others LLC | Construction | $606,604 | $612,383 | 68 | $25.5M | Research |
| Rbi Equipment Sales & Surplus, Inc. | Wholesale Trade | $474,110 | $480,102 | 33 | $10.1M | Research |
| Woodruff Chevrolet INC | Retail Trade | $378,500 | $380,782 | 27 | $6.8M | Research |
| Machine Shop Services LLC | Manufacturing | $329,800 | $332,447 | 35 | $8.6M | Research |
| Machine Shop Services LLC | Manufacturing | $329,800 | $334,020 | 32 | $7.8M | Research |
| Piedmont Bushings & Insulators, LLC | Manufacturing | $308,400 | $311,509 | 31 | $8.1M | Research |
| Quality Haulers Inc. | Transportation and Warehousing | $229,458 | $231,670 | 25 | <$5M | Research |
| Palmetto Vermiculite Co., Inc. | Manufacturing | $207,131 | $209,923 | 24 | $23.8M | Research |
| Landmark Landscape and Maintenance Service, Inc. | Professional, Scientific, and Technical Services | $195,566 | $198,116 | 36 | $7.3M | Research |
| Vaughn Curbing Company, LLC | Transportation and Warehousing | $189,447 | $191,220 | 20 | <$5M | Research |
| Woodruff Family Dentistry | Health Care and Social Assistance | $172,200 | $173,420 | 19 | <$5M | Research |
| Harrison & Son Contractors Inc. | Construction | $156,900 | $157,734 | 16 | <$5M | Research |
| Harrison & Son Contractors Inc. | Construction | $145,209 | $146,274 | 16 | <$5M | Research |
| Dreamscape LLC | Administrative and Support and Waste Management | $130,405 | $131,630 | 20 | <$5M | Research |
| Suntex Printing INC | Manufacturing | $121,900 | $123,049 | 14 | $13.9M | Research |
| Suntex Printing Inc. | Manufacturing | $121,900 | $122,671 | 11 | $10.9M | Research |
| Pol-Tech Machining, LLC | Manufacturing | $115,800 | $116,540 | 8 | <$5M | Research |
| Seegars Fence Company, Inc. of Spartanburg | Construction | $113,944 | $114,542 | 9 | <$5M | Research |
| Country Meat Center, LLC | Retail Trade | $113,547 | $114,641 | 26 | <$5M | Research |
| Harrison Landscape Management INC | Administrative and Support and Waste Management | $110,012 | $110,819 | 14 | <$5M | Research |
| Labmark LLC | Other Services (except Public Administration) | $109,611 | $110,254 | 26 | <$5M | Research |
| Dieco Manufacturing Inc. | Manufacturing | $103,420 | $104,262 | 11 | $10.9M | Research |
| Animal Clinic of Woodruff, LLC | Professional, Scientific, and Technical Services | $100,000 | $100,595 | 11 | <$5M | Research |