| Benjamin T Knutzen DDS Pl | Health Care and Social Assistance | $184,900 | $187,078 | 15 | <$5M |  Research |
| Great Plains Brown, LLC | Retail Trade | $172,600 | $173,745 | 24 | $5.2M | Research |
| Gracepoint Wesleyan Church | Other Services (except Public Administration) | $167,200 | $168,459 | 21 | N/A | Research |
| Moriarty Enterprises, Inc. | Construction | $164,700 | $166,091 | 27 | $8.4M | Research |
| Prussman Contracting Inc. | Construction | $163,700 | $164,596 | 12 | <$5M | Research |
| Prussman Contracting INC | Construction | $163,700 | $165,005 | 13 | <$5M | Research |
| Brookings Equipment Inc. | Wholesale Trade | $160,600 | $162,045 | 12 | <$5M | Research |
| Timmons Construction, Inc. | Construction | $159,500 | $161,520 | 36 | $8.3M | Research |
| Ope Niemeyer Flooring, LLC | Construction | $156,900 | $158,595 | 19 | <$5M | Research |
| Pro Pt Inc. | Health Care and Social Assistance | $154,000 | $154,915 | 13 | <$5M | Research |
| Brookings Newspapers | Information | $153,000 | $154,203 | 22 | <$5M | Research |
| Dmj, Inc. | Administrative and Support and Waste Management | $152,305 | $153,181 | 11 | <$5M | Research |
| United Development Management LLC | Construction | $150,100 | $151,463 | 24 | $8.2M | Research |
| Rgo INC | Accommodation and Food Services | $148,018 | $149,465 | 19 | <$5M | Research |
| Abm Manufacturing LLC | Construction | $142,257 | $143,106 | 14 | <$5M | Research |
| Abm Manufacturing, LLC | Construction | $142,200 | $143,436 | 14 | <$5M | Research |
| Cp Twitero PC | Health Care and Social Assistance | $139,408 | $140,233 | 16 | <$5M | Research |
| Mtr Technologies INC | Manufacturing | $139,300 | $140,538 | 19 | <$5M | Research |
| Brookings Steak Company, LLC | Accommodation and Food Services | $138,200 | $138,999 | 26 | <$5M | Research |
| Helsper, Mccarty & Rasmussen, PC | Professional, Scientific, and Technical Services | $138,105 | $138,911 | 12 | <$5M | Research |
| Cp Twitero, P.c. | Health Care and Social Assistance | $135,800 | $137,464 | 12 | <$5M | Research |
| Industrial Machine & Engineering, LLC | Manufacturing | $133,400 | $134,623 | 13 | <$5M | Research |
| Industrial Machine & Engineering LLC | Manufacturing | $133,400 | $133,830 | 11 | <$5M | Research |
| Big Sioux Veterinary Care, | Professional, Scientific, and Technical Services | $132,313 | $132,956 | 13 | <$5M | Research |
| South Dakota Agricultural Laboratories LLC | Professional, Scientific, and Technical Services | $129,800 | $131,242 | 15 | <$5M | Research |