| Cheyenne River Soiux Tribe | Health Care and Social Assistance | $502,800 | $509,054 | 64 | $10.9M |  Research |
| Cheyenne River Sioux Tribe Telephone Authority | Construction | $310,000 | $313,212 | 26 | N/A | Research |
| Sacred Heart Center | Other Services (except Public Administration) | $254,900 | $256,695 | 28 | $5.3M | Research |
| Lakota Thrify Mart | Retail Trade | $236,700 | $240,034 | 40 | $10.0M | Research |
| Eagle Butte Cooperative Association | Retail Trade | $213,015 | $214,266 | 39 | $9.7M | Research |
| Mni Waste' Water Company | Utilities | $194,840 | $154,242 | 11 | N/A | Research |
| Cheyenne River Sioux Tribe Sanitary Landfill | Administrative and Support and Waste Management | $132,900 | $133,350 | 12 | <$5M | Research |
| Cheyenne River Youth Project | Educational Services | $98,690 | $99,423 | 14 | N/A | Research |
| Cheyenne River Youth Project | Educational Services | $92,345 | $93,256 | 9 | N/A | Research |
| Cheyenne River Gas Company | Utilities | $89,877 | $90,324 | 9 | N/A | Research |
| Cheyenne River Gas Company | Utilities | $54,200 | $54,893 | 6 | N/A | Research |
| Cheyenne River Managment Corporation | Accommodation and Food Services | $52,500 | $53,115 | 12 | N/A | Research |
| Windswept Academy | Educational Services | $50,715 | $50,966 | 13 | N/A | Research |
| Number Nine Steakhouse Corp | Accommodation and Food Services | $39,788 | $40,197 | 28 | <$5M | Research |
| Wolakota Construction LLC | Construction | $38,300 | $38,836 | 3 | <$5M | Research |
| Wolakota Construction | Construction | $38,300 | $38,830 | 4 | <$5M | Research |
| Upell Medical Clinic, Prof. LLC | Health Care and Social Assistance | $38,070 | $38,319 | 6 | <$5M | Research |
| Upell Medical Clinic Prof LLC | Health Care and Social Assistance | $38,070 | $38,456 | 6 | <$5M | Research |
| Crst Kipi Radio | Information | $33,500 | $33,785 | 4 | N/A | Research |
| Mary K Gesinger | Agriculture, Forestry, Fishing and Hunting | $33,195 | $33,364 | 5 | <$5M | Research |
| All Saints Church of Eagle Butte, Sd | Other Services (except Public Administration) | $27,958 | $28,112 | 6 | <$5M | Research |
| Number Nine Steakhouse | Accommodation and Food Services | $27,956 | $28,147 | 10 | <$5M | Research |
| D & R Propane | Retail Trade | $27,585 | $27,742 | 5 | <$5M | Research |
| Oti Kaga, INC | Health Care and Social Assistance | $26,532 | $26,748 | 3 | <$5M | Research |
| Mni Mart | Retail Trade | $26,200 | $26,416 | 7 | <$5M | Research |