| Center On Aging and Health LLC | Health Care and Social Assistance | $792,500 | $797,321 | 141 | $24.0M |  Research |
| Erwin Health Care Associates, LP | Health Care and Social Assistance | $744,673 | $754,891 | 130 | $22.1M | Research |
| Impact Plastics, INC | Manufacturing | $463,651 | $468,481 | 59 | $58.5M | Research |
| Christian Care Center of Unicoi County, LLC | Health Care and Social Assistance | $400,198 | $403,699 | 48 | $8.2M | Research |
| Impact Plastics INC | Manufacturing | $389,197 | $393,651 | 59 | $58.5M | Research |
| Health and Home Care of Erwin, Inc. | Real Estate and Rental and Leasing | $165,560 | $166,756 | 27 | $12.2M | Research |
| Pals Drive Thru #26 | Accommodation and Food Services | $123,840 | $124,642 | 39 | $6.9M | Research |
| Duncan Mechanical INC | Construction | $121,708 | $122,972 | 12 | <$5M | Research |
| Unicoi Medical Associates INC | Health Care and Social Assistance | $111,837 | $112,779 | 14 | <$5M | Research |
| Erwin Dental Pllc | Health Care and Social Assistance | $108,747 | $110,001 | 11 | <$5M | Research |
| Mountain River Guides INC | Arts, Entertainment, and Recreation | $100,705 | $101,211 | 40 | $5.6M | Research |
| Tennessee Abrasive INC | Manufacturing | $100,280 | $100,854 | 11 | $10.9M | Research |
| Tennessee Abrasive INC | Manufacturing | $97,490 | $98,015 | 10 | $9.9M | Research |
| Erwin Paint and Body Shop, INC | Other Services (except Public Administration) | $93,070 | $93,827 | 13 | <$5M | Research |
| Epic Kayaks INC | Manufacturing | $92,200 | $92,877 | 5 | <$5M | Research |
| Pyranha US INC | Retail Trade | $91,197 | $92,304 | 9 | <$5M | Research |
| Valley Electric | Construction | $88,790 | $89,539 | 10 | <$5M | Research |
| Erwin Dental Pllc | Health Care and Social Assistance | $83,392 | $83,818 | 11 | <$5M | Research |
| Urgent Care of Erwin LLC | Health Care and Social Assistance | $80,538 | $81,012 | 10 | <$5M | Research |
| Unicoi County Family Ymca | Arts, Entertainment, and Recreation | $70,348 | $71,049 | 43 | N/A | Research |
| E.n.d.s Electrical Contractors INC | Construction | $70,000 | $70,338 | 8 | <$5M | Research |
| Roller Pharmacy | Retail Trade | $67,520 | $68,032 | 8 | <$5M | Research |
| E.n.d.s. Electrical Contractors INC | Construction | $64,000 | $64,233 | 12 | <$5M | Research |
| Clinchfield Drug Company | Retail Trade | $62,615 | $63,048 | 13 | <$5M | Research |
| Cunningham Dental, INC | Health Care and Social Assistance | $58,600 | $58,994 | 7 | <$5M | Research |