| Dixie Roofing, Inc. | Construction | $1,501,021 | $1,517,824 | 163 | $53.7M |  Research |
| Grace Rehabilitation Center INC | Health Care and Social Assistance | $790,992 | $793,826 | 112 | $30.2M | Research |
| Grace Rehabilitation Center, Inc. | Health Care and Social Assistance | $775,000 | $777,691 | 132 | $35.6M | Research |
| Pyro Shows INC | Arts, Entertainment, and Recreation | $595,032 | $599,263 | 31 | <$5M | Research |
| Short-Redmond Ford of Lafollette | Retail Trade | $502,500 | $508,446 | 80 | $20.2M | Research |
| K&r Italian Corporation | Accommodation and Food Services | $413,100 | $417,367 | 159 | $28.2M | Research |
| Pyro Shows, INC | Arts, Entertainment, and Recreation | $344,390 | $374,722 | 31 | <$5M | Research |
| Ellison Sanitary Supply Co., Inc. | Wholesale Trade | $237,145 | $213,111 | 22 | $5.7M | Research |
| Ayers LP | Real Estate and Rental and Leasing | $223,560 | $224,872 | 39 | $7.1M | Research |
| Terrys Pharmacy INC | Retail Trade | $193,345 | $194,513 | 32 | $5.6M | Research |
| Shotcrete Contractors INC | Construction | $163,100 | $165,030 | 11 | <$5M | Research |
| E E Hill & Son, INC | Finance and Insurance | $157,820 | $159,385 | 12 | $6.2M | Research |
| Lafollette Court Assisted and Independent Living Community, | Health Care and Social Assistance | $147,440 | $148,292 | 30 | $5.1M | Research |
| Clear Development LLC | Mining, Quarrying, and Oil and Gas Extraction | $140,629 | $141,180 | 14 | <$5M | Research |
| Access Medical Billing, Inc. | Health Care and Social Assistance | $135,000 | $108,257 | 14 | <$5M | Research |
| Riggs Drug INC | Retail Trade | $134,060 | $135,419 | 13 | <$5M | Research |
| Big O's Git & Go Market, Inc. | Retail Trade | $117,300 | $118,309 | 36 | $12.0M | Research |
| Lafollette Machine & Tool Co., Inc. | Manufacturing | $117,200 | $118,208 | 9 | <$5M | Research |
| Dr Courtney, LLC | Arts, Entertainment, and Recreation | $111,100 | $112,050 | 26 | <$5M | Research |
| Lindsay's Carpet and Paint Center INC | Wholesale Trade | $102,700 | $103,519 | 15 | <$5M | Research |
| Aquaknox Marine, LLC | Arts, Entertainment, and Recreation | $101,800 | $102,829 | 10 | <$5M | Research |
| Lafollette Health Clinic | Health Care and Social Assistance | $96,300 | $97,047 | 10 | <$5M | Research |
| Internal and Pulmonary Medicine of Lafollette, P.c. | Health Care and Social Assistance | $90,400 | $91,084 | 7 | <$5M | Research |
| Cross Smith Funderal Home INC | Other Services (except Public Administration) | $89,900 | $88,645 | 6 | <$5M | Research |
| Lyk-Nu Auto Collision & Service Center INC | Other Services (except Public Administration) | $88,700 | $88,843 | 12 | <$5M | Research |