| Speech Pathology Services of East Tennessee, LLC | Health Care and Social Assistance | $606,748 | $611,585 | 43 | $8.5M |  Research |
| Innovative Education Partnership | Educational Services | $597,000 | $601,279 | 65 | N/A | Research |
| Maryville Jamestown Opco LLC | Health Care and Social Assistance | $585,449 | $0 | 67 | $11.4M | Research |
| Blount Discount Pharmacy, Inc,. | Retail Trade | $577,800 | $583,578 | 73 | $12.7M | Research |
| Blount Gastroenterology Associates, P.c. | Health Care and Social Assistance | $540,420 | $543,451 | 43 | $13.5M | Research |
| Hepperly Auto Sales, L.l.c. | Retail Trade | $535,760 | $542,351 | 61 | $15.4M | Research |
| Industrial Commutator Corporation | Manufacturing | $525,340 | $528,722 | 32 | $8.4M | Research |
| Industrial Commutator Corporation | Manufacturing | $525,340 | $528,406 | 32 | $8.4M | Research |
| Blount Senior Care Partners, Pllc | Health Care and Social Assistance | $506,695 | $510,027 | 33 | $10.4M | Research |
| Al Blankenship Enterprises, LLC | Construction | $455,188 | $460,962 | 42 | $9.7M | Research |
| Surface Igniter LLC | Manufacturing | $449,269 | $453,974 | 56 | $14.7M | Research |
| Wireless Innovation Nation LLC | Construction | $431,400 | $433,374 | 31 | $9.6M | Research |
| Wireless Innovation Nation, LLC | Construction | $431,400 | $434,130 | 36 | $11.2M | Research |
| American Foundation and Basement Repairs | Construction | $430,000 | $433,344 | 49 | $14.9M | Research |
| Pinnacle Sales Company | Other Services (except Public Administration) | $421,200 | $424,085 | 75 | $14.7M | Research |
| Advanced Catalyst Systems LLC | Manufacturing | $414,770 | $418,722 | 33 | $8.1M | Research |
| Second Harvest Food Bank of East Tennessee | Health Care and Social Assistance | $409,301 | $414,781 | 40 | N/A | Research |
| Substance Solutions INC | Professional, Scientific, and Technical Services | $408,900 | $344,479 | 45 | $14.3M | Research |
| Substance Solutions INC | Professional, Scientific, and Technical Services | $408,900 | $413,672 | 45 | $14.3M | Research |
| Foothills Exc LLC | Construction | $402,980 | $405,398 | 30 | $10.2M | Research |
| Blue Ridge Family Dentistry Dpc | Unknown | $400,000 | $405,041 | 31 | N/A | Research |
| Crawley Corporation | Manufacturing | $396,320 | $399,230 | 31 | $8.1M | Research |
| Foothills Exc LLC | Construction | $390,220 | $395,163 | 26 | $8.1M | Research |
| East Tennessee Oral & Maxillofacial | Health Care and Social Assistance | $383,500 | $387,608 | 49 | $11.4M | Research |
| Wildcat Motor Sports LLC | Retail Trade | $381,913 | $383,336 | 31 | $8.1M | Research |