| Denton County Mhmr Center | Other Services (except Public Administration) | $4,658,487 | $3,545,628 | 351 | N/A |  Research |
| Investigative Holdings, LLC | Finance and Insurance | $4,123,300 | $3,556,807 | 380 | $195.2M | Research |
| Daybreak Therapy, L.l.c. | Health Care and Social Assistance | $4,019,800 | $4,064,624 | 431 | $116.4M | Research |
| James Wood Autopark, Inc. | Retail Trade | $2,971,500 | $3,005,367 | 242 | $61.0M | Research |
| Fisher59, LLC | Wholesale Trade | $2,669,332 | $2,704,429 | 287 | $73.9M | Research |
| Emls, Inc. | Construction | $2,429,840 | $2,458,728 | 195 | $59.2M | Research |
| D&s Engineering Labs LLC | Professional, Scientific, and Technical Services | $2,249,300 | $1,193,918 | 102 | $12.6M | Research |
| Jagoe-Public Company | Wholesale Trade | $2,168,500 | $2,192,561 | 172 | $52.7M | Research |
| Daybreak Venture, L.l.c. | Health Care and Social Assistance | $2,084,000 | $2,107,238 | 135 | $23.0M | Research |
| Emls INC | Manufacturing | $2,000,000 | $2,020,167 | 222 | $58.1M | Research |
| US Aviation Group LLC | Educational Services | $1,910,623 | $1,932,118 | 245 | $32.7M | Research |
| Bill Utter Ford Ltd | Retail Trade | $1,870,200 | $1,889,370 | 141 | $35.5M | Research |
| 4984 Classic Ltd | Retail Trade | $1,583,345 | $1,580,651 | 108 | $27.2M | Research |
| Seven Mile Cafe, LLC | Accommodation and Food Services | $1,500,500 | $1,512,257 | 118 | $21.0M | Research |
| O'reilly Hotel Partners-Denton LLC | Accommodation and Food Services | $1,444,044 | $1,456,880 | 97 | $30.3M | Research |
| Cbs Mechanical Services, Inc. | Construction | $1,344,500 | $1,354,285 | 101 | $33.2M | Research |
| Signet Health Corporation | Health Care and Social Assistance | $1,329,600 | $1,337,564 | 58 | $13.6M | Research |
| Lodc Group, Ltd | Manufacturing | $1,283,500 | $1,290,452 | 124 | $123.0M | Research |
| Health Services of North Texas INC | Health Care and Social Assistance | $1,254,200 | $1,262,633 | 112 | N/A | Research |
| Huffines Denton Autos, Inc. | Retail Trade | $1,238,472 | $1,252,666 | 90 | $22.7M | Research |
| Smile Leasing Pllc | Health Care and Social Assistance | $1,219,500 | $1,233,332 | 48 | $11.1M | Research |
| Little Guys Movers INC | Transportation and Warehousing | $1,215,600 | $1,223,560 | 182 | $45.5M | Research |
| Strategic Dental Executives, LLC | Professional, Scientific, and Technical Services | $1,205,800 | $1,290,695 | 167 | $17.3M | Research |
| Little Guys Movers Inc. | Transportation and Warehousing | $1,186,200 | $1,193,823 | 191 | $47.7M | Research |
| Links Construction, LLC | Construction | $1,179,600 | $1,187,389 | 55 | $62.7M | Research |