| United Medical Centers | Health Care and Social Assistance | $3,984,995 | $3,477,261 | 360 | N/A |  Research |
| Rio Bravo Health Systems, LLC | Health Care and Social Assistance | $1,133,800 | $1,145,390 | 420 | $71.9M | Research |
| Maverick County Hospital District | Health Care and Social Assistance | $937,200 | $944,854 | 115 | N/A | Research |
| Maverick County Hospital District | Health Care and Social Assistance | $861,600 | $865,956 | 97 | N/A | Research |
| Kickapoo Lucky Eagle Hotel, LLC | Accommodation and Food Services | $708,700 | $716,555 | 124 | $38.8M | Research |
| Eagle Pass Ford Mercury, Ltd | Retail Trade | $550,900 | $557,224 | 41 | $10.3M | Research |
| Padilla Import Sales and Marketing INC | Wholesale Trade | $441,163 | $444,325 | 35 | $9.0M | Research |
| Kttt Pan House, LLC | Accommodation and Food Services | $438,600 | $442,584 | 89 | $15.8M | Research |
| Jmj Express Carriers LLC | Transportation and Warehousing | $420,600 | $424,304 | 43 | $8.7M | Research |
| Jmj Express Carriers LLC | Transportation and Warehousing | $413,100 | $416,407 | 46 | $9.3M | Research |
| Mh Group LLC | Transportation and Warehousing | $338,040 | $340,726 | 30 | $6.0M | Research |
| Med Shield Ambulance Inc. | Health Care and Social Assistance | $316,200 | $319,353 | 41 | $9.5M | Research |
| Vu Acquisitions | Manufacturing | $311,440 | $317,124 | 79 | $22.1M | Research |
| Guva's Enterprises LLC | Accommodation and Food Services | $311,369 | $313,272 | 46 | $8.2M | Research |
| Brown Chevrolet-Buick-Gmc of Eagle Pass, Inc. | Wholesale Trade | $309,342 | $312,582 | 33 | $10.1M | Research |
| Med Shield Ambulance LLC | Wholesale Trade | $285,500 | $287,863 | 57 | $17.5M | Research |
| Thermavue Solutions INC | Professional, Scientific, and Technical Services | $273,500 | $275,779 | 32 | <$5M | Research |
| Claymex Brick & Tile, INC | Wholesale Trade | $272,500 | $274,831 | 27 | $8.3M | Research |
| Mh Group LLC | Transportation and Warehousing | $257,328 | $259,343 | 33 | $12.8M | Research |
| Parts Service Supply, Co. | Retail Trade | $250,200 | $252,633 | 25 | $6.8M | Research |
| Thermavue Solutions INC | Construction | $240,800 | $243,027 | 35 | $11.5M | Research |
| Aguila Express LLC | Transportation and Warehousing | $236,800 | $239,082 | 31 | $6.2M | Research |
| Eliezer Hernandez, Mdpa | Health Care and Social Assistance | $224,300 | $226,238 | 20 | $6.3M | Research |
| Parts Service Supply Co. | Retail Trade | $223,900 | $225,697 | 26 | $7.0M | Research |
| Guva's Enterprises LLC | Accommodation and Food Services | $222,407 | $224,791 | 5 | <$5M | Research |