| Lone Star Calf Ranch LP | Agriculture, Forestry, Fishing and Hunting | $1,984,700 | $2,003,786 | 230 | $37.6M |  Research |
| Deaf Smith County Hospital District | Health Care and Social Assistance | $1,981,582 | $2,002,334 | 210 | N/A | Research |
| Panhandle Express, LLC | Transportation and Warehousing | $1,263,505 | $1,270,566 | 96 | $14.5M | Research |
| Deaf Smith Electric Cooperative Inc. | Utilities | $1,221,236 | $1,233,381 | 55 | N/A | Research |
| Miguel Dairy Service and Supply Inc. | Manufacturing | $1,002,139 | $1,008,291 | 63 | $22.2M | Research |
| Miguel Dairy Service and Supply, Inc. | Wholesale Trade | $970,530 | $981,691 | 68 | $20.8M | Research |
| Barrett & Crofoot Feedyards LLP | Agriculture, Forestry, Fishing and Hunting | $950,300 | $958,527 | 115 | $18.8M | Research |
| Integrity Ag, Inc. | Transportation and Warehousing | $758,835 | $767,393 | 57 | $8.6M | Research |
| D & J Dairy | Agriculture, Forestry, Fishing and Hunting | $735,700 | $739,889 | 95 | $15.5M | Research |
| Ferrell-Ross Roll Manufacturing Inc. | Construction | $727,442 | $734,459 | 68 | $11.7M | Research |
| Champion Feeders, LLC | Agriculture, Forestry, Fishing and Hunting | $727,300 | $733,437 | 60 | $9.8M | Research |
| Ferrell-Ross Roll Manufacturing Inc. | Manufacturing | $726,129 | $730,324 | 60 | $14.7M | Research |
| Cnossen Dairy LLC | Agriculture, Forestry, Fishing and Hunting | $648,805 | $652,911 | 99 | $16.2M | Research |
| We Hereford, LLC | Manufacturing | $642,491 | $650,536 | 44 | $43.6M | Research |
| West Texas Rural Telephone Cooperative, Inc. | Information | $627,400 | $630,889 | 37 | $6.2M | Research |
| Texas Agriplex LLC | Agriculture, Forestry, Fishing and Hunting | $620,070 | $623,653 | 42 | <$5M | Research |
| Hereford Grain Corporation | Manufacturing | $598,540 | $602,164 | 55 | $19.4M | Research |
| Hereford Grain Corporation | Transportation and Warehousing | $597,990 | $601,927 | 55 | $14.0M | Research |
| North Star Dairy LLC | Agriculture, Forestry, Fishing and Hunting | $583,077 | $590,608 | 75 | $12.3M | Research |
| Colliers Top of Texas INC | Construction | $553,200 | $555,746 | 44 | $14.0M | Research |
| Mission Dairy | Agriculture, Forestry, Fishing and Hunting | $528,294 | $535,088 | 64 | $10.5M | Research |
| Friendship Dairies | Agriculture, Forestry, Fishing and Hunting | $525,461 | $531,825 | 59 | $9.7M | Research |
| Collier's Top of Texas INC | Construction | $480,700 | $484,078 | 44 | $13.6M | Research |
| Mc6 Cattle Feeders Inc. | Agriculture, Forestry, Fishing and Hunting | $470,400 | $474,318 | 55 | $9.0M | Research |
| 3mk Construction LLC | Construction | $468,983 | $471,863 | 52 | $12.0M | Research |