| Border Region Mhmr Community Center | Health Care and Social Assistance | $8,258,970 | $2,943,563 | 336 | N/A |  Research |
| Super Transport International Ltd | Transportation and Warehousing | $2,906,900 | $2,939,792 | 283 | $57.0M | Research |
| Champion Care, Inc. | Health Care and Social Assistance | $2,815,745 | $2,851,694 | 500 | $85.6M | Research |
| Gateway Community Health Center, INC | Health Care and Social Assistance | $2,781,055 | $2,818,522 | 260 | N/A | Research |
| A E D - Associates INC | Accommodation and Food Services | $2,498,200 | $2,527,484 | 500 | $88.8M | Research |
| Rainbow Pizza, L.l.c. | Accommodation and Food Services | $2,152,381 | $2,177,253 | 500 | $88.8M | Research |
| Arguindegui Oil Company Ii, Ltd | Wholesale Trade | $2,085,600 | $2,109,256 | 167 | $43.0M | Research |
| Super Transport International Ltd. | Transportation and Warehousing | $2,000,000 | $2,014,795 | 218 | $43.9M | Research |
| Arguindegui Oil Company Company II Ltd | Wholesale Trade | $1,968,502 | $1,980,367 | 203 | $52.3M | Research |
| Killam Oil Co. Ltd. | Mining, Quarrying, and Oil and Gas Extraction | $1,887,300 | $1,902,294 | 117 | $7.1M | Research |
| Pw Health Services LLC | Health Care and Social Assistance | $1,770,053 | $1,781,514 | 186 | $31.9M | Research |
| Elite Employment Services LLC | Administrative and Support and Waste Management | $1,700,000 | $1,717,331 | 394 | $62.0M | Research |
| Royal Express Inc. | Transportation and Warehousing | $1,695,500 | $1,705,627 | 203 | $40.9M | Research |
| Friendly Care Primary Services, LLC | Health Care and Social Assistance | $1,572,365 | $1,600,406 | 500 | $85.6M | Research |
| Powell Watson Motors Inc. | Retail Trade | $1,562,600 | $1,583,492 | 162 | $40.8M | Research |
| Sames Motor Company, Inc. | Retail Trade | $1,561,000 | $1,574,095 | 154 | $38.8M | Research |
| Royal Express, Inc. | Transportation and Warehousing | $1,509,200 | $1,519,950 | 187 | $37.7M | Research |
| Border Wells Services, INC | Mining, Quarrying, and Oil and Gas Extraction | $1,478,500 | $1,500,513 | 63 | <$5M | Research |
| Killam Oil Co. Ltd | Mining, Quarrying, and Oil and Gas Extraction | $1,442,058 | $1,453,274 | 92 | $5.6M | Research |
| Estrella Provider Services, Llc. | Health Care and Social Assistance | $1,410,300 | $1,437,192 | 500 | $85.6M | Research |
| Danny's Dining INC | Accommodation and Food Services | $1,348,200 | $1,356,439 | 224 | $39.8M | Research |
| Gonzalez Weed Control & Construction, Inc. | Construction | $1,292,030 | $1,315,003 | 69 | $23.5M | Research |
| Turimex, LLC | Transportation and Warehousing | $1,239,703 | $1,246,868 | 188 | $72.3M | Research |
| Dicex International, Inc. | Professional, Scientific, and Technical Services | $1,236,100 | $1,245,027 | 157 | $16.2M | Research |
| Gonzalez Weed Control & Construction, Inc. | Administrative and Support and Waste Management | $1,205,850 | $1,231,816 | 65 | $14.1M | Research |