| Frio Hospital Association | Health Care and Social Assistance | $1,370,949 | $1,378,724 | 121 | N/A | AI Deep Dive |
| Grande Oilfield LLC | Mining, Quarrying, and Oil and Gas Extraction | $678,500 | $683,258 | 31 | <$5M | AI Deep Dive |
| Grande Oilfield, LLC | Mining, Quarrying, and Oil and Gas Extraction | $649,200 | $653,824 | 101 | $6.1M | AI Deep Dive |
| Bull's Eye Services LLC | Utilities | $439,200 | $443,171 | 23 | N/A | AI Deep Dive |
| Bull's Eye Services LLC | Construction | $439,200 | $440,945 | 23 | $7.1M | AI Deep Dive |
| Frio County Partners INC | Wholesale Trade | $302,877 | $305,839 | 22 | $5.7M | AI Deep Dive |
| Oscar Garza MD PA | Health Care and Social Assistance | $195,700 | $197,453 | 23 | $7.2M | AI Deep Dive |
| Gary Boyd Farms, Gp | Agriculture, Forestry, Fishing and Hunting | $163,880 | $165,425 | 17 | <$5M | AI Deep Dive |
| Gulley Trucking INC | Construction | $139,366 | $140,485 | 11 | <$5M | AI Deep Dive |
| Gulley Trucking Inc. | Transportation and Warehousing | $128,427 | $128,797 | 11 | <$5M | AI Deep Dive |
| Los Cazadores Operations, LLC | Wholesale Trade | $123,680 | $124,676 | 18 | $5.5M | AI Deep Dive |
| First A-1 Electric INC | Construction | $89,605 | $90,305 | 10 | <$5M | AI Deep Dive |
| Alpha Tanks & Pump II LLC | Mining, Quarrying, and Oil and Gas Extraction | $89,100 | $89,950 | 5 | <$5M | AI Deep Dive |
| John Montemayor | Transportation and Warehousing | $86,700 | $87,208 | 1 | <$5M | AI Deep Dive |
| Cowpokes Daily Bread LLC | Accommodation and Food Services | $84,781 | $85,124 | 11 | <$5M | AI Deep Dive |
| Used Cars INC | Finance and Insurance | $82,625 | $82,933 | 6 | <$5M | AI Deep Dive |
| Used Cars INC | Wholesale Trade | $82,625 | $83,293 | 6 | <$5M | AI Deep Dive |
| Kinsman Farms | Agriculture, Forestry, Fishing and Hunting | $82,049 | $82,827 | 12 | <$5M | AI Deep Dive |
| Pearsall Livestock Auction Inc. | Agriculture, Forestry, Fishing and Hunting | $81,341 | $81,598 | 25 | <$5M | AI Deep Dive |
| Hurley Funeral Home of Lytle & Pearsal | Other Services (except Public Administration) | $78,200 | $78,631 | 24 | <$5M | AI Deep Dive |
| Pearsall Milan LLC | Accommodation and Food Services | $74,155 | $74,787 | 15 | <$5M | AI Deep Dive |
| Sonic Drive in Pearsall Texas Ltd | Accommodation and Food Services | $73,500 | $74,270 | 15 | <$5M | AI Deep Dive |
| Pearsall Livestock Auction INC | Agriculture, Forestry, Fishing and Hunting | $72,528 | $73,126 | 12 | <$5M | AI Deep Dive |
| Virga Consulting LLC | Mining, Quarrying, and Oil and Gas Extraction | $71,875 | $72,767 | 1 | <$5M | AI Deep Dive |
| Adt Systems INC | Administrative and Support and Waste Management | $63,700 | $64,169 | 8 | <$5M | AI Deep Dive |