| Spirit Trucking Lines INC | Transportation and Warehousing | $3,279,800 | $3,317,244 | 430 | $86.6M |  Research |
| Cano and Sons Trucking LLC | Transportation and Warehousing | $2,800,460 | $1,182,712 | 122 | $18.4M | Research |
| Alegria Primary Home Care INC | Health Care and Social Assistance | $2,681,400 | $2,718,865 | 500 | $85.6M | Research |
| Nuestra Clinica Del Valle, Inc. | Health Care and Social Assistance | $2,108,500 | $2,132,185 | 284 | N/A | Research |
| Rio Fresh INC | Agriculture, Forestry, Fishing and Hunting | $1,323,700 | $1,335,503 | 176 | $18.0M | Research |
| Grande Produce, Ltd. Co. | Retail Trade | $931,579 | $944,543 | 150 | $16.7M | Research |
| San Juan Nursing Home INC | Health Care and Social Assistance | $835,540 | $840,416 | 110 | $18.7M | Research |
| San Juan Nursing Home INC | Health Care and Social Assistance | $835,500 | $840,105 | 129 | $21.9M | Research |
| Americare Nursing Services | Health Care and Social Assistance | $765,500 | $775,452 | 456 | $78.1M | Research |
| San Juan Motors LLC | Retail Trade | $727,700 | $732,693 | 54 | $13.6M | Research |
| Heller Bird Lll Ltd. | Retail Trade | $640,000 | $643,437 | 50 | $12.6M | Research |
| Basilica of Our Lady of San Juan Del Valle - National Shrine | Other Services (except Public Administration) | $629,300 | $636,764 | 108 | $20.6M | Research |
| Basilica of the National Shrine of Our Lady of San Juan Del | Other Services (except Public Administration) | $629,300 | $633,495 | 108 | $20.6M | Research |
| Heller Bird Lll Ltd. | Retail Trade | $602,300 | $606,260 | 61 | $15.4M | Research |
| Central Ready Mix Concrete Co | Manufacturing | $512,355 | $515,191 | 58 | $57.5M | Research |
| Vilico Management LLC | Information | $430,032 | $436,435 | 19 | <$5M | Research |
| Aguilar Meat Market #2, Inc. | Retail Trade | $344,692 | $346,831 | 87 | $9.7M | Research |
| La Union Del Pueblo Entero | Public Administration | $301,000 | $304,403 | 38 | N/A | Research |
| Heller-Bird V Ltd. | Retail Trade | $299,000 | $300,466 | 29 | $7.3M | Research |
| Heller-Bird V, Ltd. | Retail Trade | $295,600 | $297,544 | 39 | $9.8M | Research |
| Texas Music Festivals Enterprise, Inc. | Administrative and Support and Waste Management | $295,382 | $298,598 | 41 | $13.0M | Research |
| Pacam Transport LLC | Transportation and Warehousing | $258,497 | $261,245 | 38 | $7.7M | Research |
| La Union Del Pueblo Entero | Other Services (except Public Administration) | $251,500 | $304,512 | 51 | N/A | Research |
| Dewey Young | Finance and Insurance | $250,277 | $252,368 | 18 | $9.2M | Research |
| Texas Music Festivals Enterprise INC | Retail Trade | $249,107 | $251,384 | 29 | <$5M | Research |