| David Hamer, M.d. PA | Health Care and Social Assistance | $617,000 | $620,313 | 45 | $14.1M |  Research |
| Dermatological Association of Texas | Health Care and Social Assistance | $595,065 | $602,437 | 32 | $6.3M | Research |
| Tri-Sen Systems Corporation | Manufacturing | $584,375 | $590,379 | 27 | $6.6M | Research |
| Shelter Roofing LP | Construction | $518,048 | $521,681 | 42 | $13.8M | Research |
| Ansh Labs LLC | Health Care and Social Assistance | $516,624 | $522,158 | 30 | $7.0M | Research |
| Raelin Ventures, LLC | Accommodation and Food Services | $513,000 | $517,090 | 146 | $25.9M | Research |
| Webster Etc, LLC | Management of Companies and Enterprises | $508,276 | $513,924 | 90 | $14.8M | Research |
| Shelter Roofing LP | Construction | $501,217 | $506,545 | 32 | $10.5M | Research |
| Mamacitas On the Bay No 2 INC | Accommodation and Food Services | $499,713 | $504,863 | 67 | $11.9M | Research |
| Demontrond Clear Lake, LLC | Retail Trade | $497,100 | $502,637 | 39 | $9.8M | Research |
| Newlife Brace & Limb LLC | Manufacturing | $496,717 | $502,153 | 15 | <$5M | Research |
| Healthcare Specialists, Pllc | Health Care and Social Assistance | $485,303 | $489,306 | 30 | $9.4M | Research |
| Ariarmaturen Usa, LP | Manufacturing | $483,000 | $485,408 | 29 | $7.1M | Research |
| Heartis Clear Lake Partners, LP | Health Care and Social Assistance | $479,195 | $482,700 | 87 | $14.8M | Research |
| Afg Webster LLC | Accommodation and Food Services | $464,770 | $468,346 | 77 | $13.7M | Research |
| Pluckers-Webster, LLC | Accommodation and Food Services | $444,000 | $447,737 | 123 | $21.8M | Research |
| Clear Lake Emergency Medical Corps. | Health Care and Social Assistance | $436,900 | $297,828 | 25 | N/A | Research |
| Steve Wolverton | Finance and Insurance | $420,300 | $424,641 | 33 | $17.0M | Research |
| Ascher Building & Design LLC | Construction | $416,687 | $326,381 | 112 | $127.6M | Research |
| Lewis Jewelers, Inc. | Retail Trade | $411,200 | $415,746 | 23 | $6.4M | Research |
| Bay Area Turning Point, INC | Health Care and Social Assistance | $403,800 | $293,413 | 43 | N/A | Research |
| South Atlantic and Gulf Coat District Ila | Other Services (except Public Administration) | $401,200 | $404,607 | 38 | N/A | Research |
| Pulmonary & Sleep Physicians of Houston, PA | Health Care and Social Assistance | $400,800 | $377,625 | 33 | $10.4M | Research |
| Chad T. Wilson Law Firm Pllc | Professional, Scientific, and Technical Services | $389,000 | $391,824 | 23 | $5.6M | Research |
| Mohamed S. Ahmed, M.d. P.a. | Health Care and Social Assistance | $377,700 | $295,721 | 36 | $11.3M | Research |