| Sog International Staffing, LLC | Administrative and Support and Waste Management | $2,670,370 | $2,700,512 | 500 | $78.7M |  Research |
| Regional Nursing Services Inc. | Health Care and Social Assistance | $1,745,000 | $1,763,323 | 500 | $85.6M | Research |
| S.e.s.a Fleet Services LLC | Manufacturing | $1,688,180 | $1,708,901 | 138 | $36.1M | Research |
| S.e.s.a. Fleet Services, L.l.c. | Mining, Quarrying, and Oil and Gas Extraction | $1,688,100 | $1,607,080 | 138 | $8.4M | Research |
| South Texas Educational Technologies Inc. | Educational Services | $1,373,400 | $1,381,869 | 212 | N/A | Research |
| Weslaco Motors, L.p. | Retail Trade | $1,326,915 | $1,339,852 | 137 | $34.5M | Research |
| Thurmond Eye Associates PA | Health Care and Social Assistance | $1,208,100 | $1,214,753 | 148 | $46.5M | Research |
| Adl Services INC | Health Care and Social Assistance | $1,092,565 | $1,103,612 | 392 | $67.1M | Research |
| Ed Payne Motors LLP | Retail Trade | $1,038,700 | $1,049,713 | 97 | $24.4M | Research |
| Weslaco Ford Mercury LLP | Retail Trade | $911,744 | $920,532 | 93 | $23.4M | Research |
| Vgm Valley Grande Manor Weslaco Ops, INC | Health Care and Social Assistance | $872,500 | $881,589 | 258 | $43.9M | Research |
| Extreme Well Testing, LLC | Mining, Quarrying, and Oil and Gas Extraction | $834,700 | $839,731 | 42 | <$5M | Research |
| Extreme Well Testing LLC | Mining, Quarrying, and Oil and Gas Extraction | $834,700 | $838,245 | 39 | <$5M | Research |
| P.a.c.e. Health Care INC | Health Care and Social Assistance | $811,400 | $822,872 | 285 | $48.8M | Research |
| Rio Grande Valley Adult & Internal Medicine Specialist PA | Health Care and Social Assistance | $803,600 | $812,507 | 118 | $37.0M | Research |
| Con Carino, INC | Health Care and Social Assistance | $788,300 | $798,723 | 262 | $42.4M | Research |
| Odp Mgmt LLC | Health Care and Social Assistance | $784,655 | $792,480 | 364 | $62.3M | Research |
| El Rey Primary Healthcare LLC | Health Care and Social Assistance | $757,700 | $763,341 | 306 | $52.4M | Research |
| Bpg, LLC | Health Care and Social Assistance | $688,200 | $695,723 | 267 | $45.7M | Research |
| Payne Dealer Group Management Co., Inc. | Retail Trade | $682,728 | $690,105 | 70 | $17.6M | Research |
| Pas Home Care LLC | Health Care and Social Assistance | $627,900 | $2,425,354 | 201 | $34.4M | Research |
| John Knox Villages of the Lower Rio Grande Valley INC | Health Care and Social Assistance | $600,000 | $602,917 | 99 | N/A | Research |
| My Wireless Texas, Inc. | Information | $594,700 | $601,869 | 105 | $17.6M | Research |
| John Knox Villages of the Lower Rio Grande | Health Care and Social Assistance | $575,992 | $579,148 | 113 | N/A | Research |
| Chris Fann and Associates, LLC | Transportation and Warehousing | $566,600 | $571,521 | 40 | <$5M | Research |