| Riggs Oil Company INC | Retail Trade | $894,500 | $904,290 | 200 | $66.9M |  Research |
| Quesenberry's Inc. | Construction | $548,500 | $551,716 | 45 | $51.3M | Research |
| Quesenberry's, Inc. | Construction | $536,900 | $540,357 | 49 | $55.8M | Research |
| Southern Forest Products, LLC | Agriculture, Forestry, Fishing and Hunting | $506,500 | $512,009 | 56 | $5.7M | Research |
| Lonesome Pine Dining Inc. | Accommodation and Food Services | $410,347 | $415,721 | 78 | $13.8M | Research |
| South-West Insurance Agency, Inc. | Finance and Insurance | $347,100 | $349,404 | 30 | $15.4M | Research |
| Lonesome Pine Dining, Inc. | Construction | $294,300 | $298,138 | 83 | $25.7M | Research |
| Tuck Mapping Solutions, Inc. | Professional, Scientific, and Technical Services | $262,700 | $264,183 | 18 | <$5M | Research |
| Auto World of Big Stone Gap | Retail Trade | $261,462 | $262,813 | 23 | $5.8M | Research |
| Tuck Mapping Solutions Inc. | Professional, Scientific, and Technical Services | $249,500 | $250,450 | 18 | <$5M | Research |
| Auto World of Big Stone Gap, Inc. | Retail Trade | $248,857 | $250,516 | 32 | $8.1M | Research |
| Dotson Chevrolet, Inc. | Retail Trade | $170,900 | $172,014 | 25 | $6.3M | Research |
| Curklin's LLC | Accommodation and Food Services | $168,000 | $169,041 | 45 | $8.0M | Research |
| Infinity Medical Management LLC | Health Care and Social Assistance | $165,568 | $169,252 | 20 | <$5M | Research |
| Family Drug, Inc. | Retail Trade | $145,800 | $147,202 | 19 | <$5M | Research |
| Curklin's LLC | Accommodation and Food Services | $141,371 | $142,600 | 23 | <$5M | Research |
| Kevin M. Allred D.d.s. P.c. | Health Care and Social Assistance | $141,155 | $142,837 | 16 | <$5M | Research |
| Kevin M Allred, DDS PC | Health Care and Social Assistance | $132,500 | $134,072 | 15 | <$5M | Research |
| Bresee Trucking, Inc. | Transportation and Warehousing | $115,320 | $116,278 | 24 | $6.4M | Research |
| Drs. Botts and Botts, Optometrists | Health Care and Social Assistance | $108,700 | $109,754 | 11 | <$5M | Research |
| Lonesome Pine Lodging Inc. | Accommodation and Food Services | $107,900 | $109,133 | 29 | $9.1M | Research |
| Drs. Botts and Botts Optometrists P.c. | Health Care and Social Assistance | $102,800 | $103,901 | 13 | <$5M | Research |
| Southern Stoneworks LLC | Mining, Quarrying, and Oil and Gas Extraction | $88,000 | $88,726 | 16 | <$5M | Research |
| Union Drug Inc. | Retail Trade | $86,100 | $86,817 | 9 | <$5M | Research |
| C Group Insurance LLC | Finance and Insurance | $84,600 | $85,414 | 7 | <$5M | Research |