| Roman Eagle Rehabilitation and Health Care Center INC | Health Care and Social Assistance | $3,289,600 | $3,327,430 | 353 | N/A |  Research |
| Averett University of Danville Virginia | Educational Services | $3,186,000 | $3,242,729 | 486 | N/A | Research |
| Danchem Technologies, Inc. | Manufacturing | $1,974,900 | $1,997,109 | 200 | $70.6M | Research |
| Piedmont Access to Health Services, Inc. | Health Care and Social Assistance | $1,966,200 | $1,984,839 | 182 | N/A | Research |
| Ebi LLC | Manufacturing | $1,950,321 | $1,971,641 | 274 | $71.7M | Research |
| Ebi LLC | Manufacturing | $1,928,900 | $1,940,527 | 241 | $63.1M | Research |
| Commonwealth Home Health Care Inc. | Health Care and Social Assistance | $1,395,000 | $1,403,835 | 247 | $42.3M | Research |
| Infinity Global INC | Wholesale Trade | $1,354,498 | $1,363,791 | 100 | $30.6M | Research |
| Infinity Global Inc. | Wholesale Trade | $1,354,400 | $1,361,435 | 93 | $28.5M | Research |
| Catie Food Systems, Inc. | Accommodation and Food Services | $1,255,700 | $1,267,879 | 250 | $44.4M | Research |
| Riverside Roof Truss, Inc. | Manufacturing | $1,200,500 | $1,006,013 | 108 | $107.1M | Research |
| Robert Woodall Chevrolet, Inc. | Wholesale Trade | $1,040,917 | $1,053,263 | 97 | $29.7M | Research |
| Spectrum Medical, Inc. | Health Care and Social Assistance | $1,029,800 | $1,035,550 | 100 | $31.4M | Research |
| Shirley May Restaurant Group, Inc. | Accommodation and Food Services | $959,900 | $969,210 | 200 | $35.5M | Research |
| Negril Incorporated | Other Services (except Public Administration) | $876,469 | $885,696 | 138 | $26.4M | Research |
| Negril, INC | Health Care and Social Assistance | $876,400 | $887,745 | 175 | $54.9M | Research |
| Bacon Enterprises Inc. | Accommodation and Food Services | $853,100 | $861,584 | 210 | $37.3M | Research |
| Pmj Automotive, LLC | Retail Trade | $835,505 | $746,545 | 65 | $16.4M | Research |
| Piedmont Precision Machine Co INC | Manufacturing | $774,835 | $784,779 | 78 | $19.1M | Research |
| Danville Urologic Clinic, Inc. | Health Care and Social Assistance | $707,400 | $716,490 | 75 | $23.5M | Research |
| Lawrence Distributing Company INC | Wholesale Trade | $631,000 | $635,557 | 78 | $20.1M | Research |
| Danville Dental Associates P.c. | Health Care and Social Assistance | $606,864 | $610,657 | 74 | $17.1M | Research |
| Danville Dental Associates, P.c. | Health Care and Social Assistance | $602,776 | $606,208 | 79 | $18.3M | Research |
| Center for Pediatrci Therapies Inc. | Health Care and Social Assistance | $597,400 | $601,934 | 76 | $20.5M | Research |
| Danville Distributing Co. | Wholesale Trade | $545,477 | $551,083 | 50 | $12.9M | Research |