| Scott County Telephone Cooperative | Information | $1,123,956 | $1,131,931 | 62 | $10.4M |  Research |
| Pals Drive Thru #7 | Accommodation and Food Services | $170,805 | $172,779 | 71 | $12.6M | Research |
| Smith Electrical Contractors Inc. | Construction | $146,302 | $147,224 | 13 | <$5M | Research |
| Smith Electrical Contractors Inc. | Construction | $139,200 | $140,523 | 13 | <$5M | Research |
| David E. Templeton, Dds,pc | Health Care and Social Assistance | $116,281 | $117,279 | 6 | <$5M | Research |
| David E. Templeton D.d.s. P.c. | Health Care and Social Assistance | $113,555 | $85,131 | 8 | <$5M | Research |
| Appalachian Community Action & Development Agency, Inc. | Health Care and Social Assistance | $101,467 | $102,143 | 17 | N/A | Research |
| Photogenius/image Consultants | Professional, Scientific, and Technical Services | $90,550 | $91,170 | 12 | <$5M | Research |
| Jeffrey D Montgomery DDS PC | Health Care and Social Assistance | $79,905 | $80,824 | 10 | <$5M | Research |
| Repko Family Vision Center Pllc | Health Care and Social Assistance | $76,023 | $76,242 | 12 | <$5M | Research |
| Therapy Innovations, Inc. | Health Care and Social Assistance | $74,895 | $75,448 | 8 | <$5M | Research |
| Gate City Funeral Home, Inc. | Other Services (except Public Administration) | $74,460 | $107,325 | 23 | <$5M | Research |
| Bobby Watlington | Professional, Scientific, and Technical Services | $63,758 | $64,005 | 11 | <$5M | Research |
| Scott County Lifesaving & First Aid Crew, Inc. | Health Care and Social Assistance | $58,322 | $58,789 | 9 | N/A | Research |
| Scott County Lifesaving & First Aid Crew Incorporated | Health Care and Social Assistance | $58,320 | $58,594 | 12 | N/A | Research |
| Wray W Chaffin Ii,dmd, PC | Health Care and Social Assistance | $57,300 | $60,575 | 5 | <$5M | Research |
| Hob-Nob-Drive in | Accommodation and Food Services | $55,230 | $55,760 | 18 | <$5M | Research |
| Scott Veterinary Services Inc. | Professional, Scientific, and Technical Services | $53,250 | $53,611 | 7 | <$5M | Research |
| Broadwater Veterinary Hospital ,inc. | Professional, Scientific, and Technical Services | $46,300 | $46,674 | 6 | <$5M | Research |
| Ross Jenkins | Accommodation and Food Services | $45,750 | $45,971 | 16 | <$5M | Research |
| Commonwealth Title Services, Inc. | Professional, Scientific, and Technical Services | $45,454 | $45,730 | 6 | <$5M | Research |
| Smartbpo, Llc. | Utilities | $41,668 | $41,890 | 2 | N/A | Research |
| Smartbpo, Llc. | Professional, Scientific, and Technical Services | $41,600 | $41,899 | 2 | <$5M | Research |
| Valley View Animal Clinic,inc | Professional, Scientific, and Technical Services | $40,193 | $40,516 | 5 | <$5M | Research |
| Thecampus LLC | Accommodation and Food Services | $36,852 | $37,000 | 12 | <$5M | Research |