| New Virginia Tractor, LLC | Other Services (except Public Administration) | $1,393,800 | $1,402,782 | 122 | $23.9M |  Research |
| American Color, Inc. | Agriculture, Forestry, Fishing and Hunting | $1,100,000 | $1,109,900 | 170 | $17.4M | Research |
| Orange-Madison Cooperative Farm Service | Wholesale Trade | $948,869 | $957,751 | 89 | $22.9M | Research |
| Reynolds Chevrolet Buick Gmc Cadillac | Retail Trade | $752,500 | $757,788 | 59 | $14.9M | Research |
| Hew INC | Accommodation and Food Services | $518,900 | $522,244 | 129 | $22.9M | Research |
| Willow Grove Inn LLC | Accommodation and Food Services | $459,011 | $463,601 | 50 | $15.6M | Research |
| Orange County Senior Living, INC | Health Care and Social Assistance | $405,800 | $409,689 | 67 | N/A | Research |
| James R Bailey Hauling LLC | Transportation and Warehousing | $375,000 | $380,052 | 31 | <$5M | Research |
| Ridgeview New Holland INC | Wholesale Trade | $355,058 | $358,027 | 26 | $8.0M | Research |
| Grelen Nursery INC | Agriculture, Forestry, Fishing and Hunting | $354,200 | $356,611 | 50 | $5.1M | Research |
| Grymes Memorial School | Educational Services | $328,000 | $330,032 | 44 | N/A | Research |
| H. B. Sedwick, Jr Building Supply, INC | Retail Trade | $285,373 | $288,047 | 41 | $8.5M | Research |
| Williams Lawncare and Landscaping Inc. | Administrative and Support and Waste Management | $259,733 | $262,777 | 30 | $6.5M | Research |
| Williams Lawncare and Landscaping INC | Administrative and Support and Waste Management | $259,700 | $262,780 | 30 | $6.5M | Research |
| Willow Grove Inn LLC | Accommodation and Food Services | $240,200 | $241,521 | 44 | $13.8M | Research |
| Piedmont Power Sports Llc. | Wholesale Trade | $223,659 | $226,076 | 25 | $7.7M | Research |
| Orange Cycles, LLC | Unknown | $219,100 | $0 | 19 | N/A | Research |
| Piedmont Power Sports Inc. | Manufacturing | $209,015 | $210,664 | 22 | $5.8M | Research |
| Pro Collision Center, LLC | Other Services (except Public Administration) | $197,300 | $199,432 | 15 | <$5M | Research |
| Orange Tire INC | Real Estate and Rental and Leasing | $152,700 | $153,650 | 11 | <$5M | Research |
| Piedmont Regional Dental Clinic INC | Health Care and Social Assistance | $148,195 | $148,965 | 11 | N/A | Research |
| Piedmont Regional Dental Clinic, INC | Health Care and Social Assistance | $148,100 | $149,096 | 13 | N/A | Research |
| Wrights Iron Inc. | Manufacturing | $142,500 | $143,391 | 14 | <$5M | Research |
| Blacksmith Properties LLC | Accommodation and Food Services | $139,400 | $140,593 | 34 | $6.0M | Research |
| Lamar and Seymour, LLC | Retail Trade | $117,837 | $118,975 | 11 | <$5M | Research |