| Counts Drug Company, INC | Retail Trade | $131,000 | $131,873 | 19 | <$5M |  Research |
| Np Wytheville Hotel Inc. | Accommodation and Food Services | $130,773 | $131,612 | 22 | $6.9M | Research |
| Devlan Hospitality LLC | Accommodation and Food Services | $130,036 | $130,763 | 21 | $6.6M | Research |
| United Investors Virginia Lc | Accommodation and Food Services | $129,500 | $130,460 | 28 | $8.8M | Research |
| Cycles of Wytheville | Retail Trade | $129,400 | $130,924 | 15 | <$5M | Research |
| Complete Truck Service Inc. | Transportation and Warehousing | $124,033 | $124,794 | 12 | <$5M | Research |
| Five Greens Restaurant, Inc. | Accommodation and Food Services | $123,700 | $124,483 | 59 | $10.5M | Research |
| Vidon INC | Accommodation and Food Services | $123,699 | $124,414 | 26 | <$5M | Research |
| Complete Truck Service, INC | Other Services (except Public Administration) | $121,800 | $122,547 | 13 | <$5M | Research |
| Home & Commercial Cleaning & Property Maintenance INC | Administrative and Support and Waste Management | $119,820 | $121,245 | 30 | $6.5M | Research |
| Home & Commercial Property Maintenance, INC | Administrative and Support and Waste Management | $119,800 | $121,198 | 30 | $6.5M | Research |
| Community Animal Clinic INC | Professional, Scientific, and Technical Services | $118,900 | $119,689 | 13 | <$5M | Research |
| Southeast Logistics, Inc. | Transportation and Warehousing | $115,782 | $117,333 | 15 | <$5M | Research |
| Southeast Logistics Inc. | Transportation and Warehousing | $115,670 | $116,301 | 17 | <$5M | Research |
| Raga Corp | Accommodation and Food Services | $114,056 | $114,662 | 17 | $5.3M | Research |
| 276 Express LLC | Transportation and Warehousing | $113,900 | $115,048 | 22 | $6.8M | Research |
| Mbjm Corporation | Accommodation and Food Services | $110,800 | $111,865 | 30 | $9.4M | Research |
| Brock Hughes Free Clinic, Inc. | Health Care and Social Assistance | $110,500 | $111,123 | 12 | N/A | Research |
| Town of Wytheville | Administrative and Support and Waste Management | $105,000 | $105,449 | 14 | N/A | Research |
| Interstate Total Retail Solutionc LLC | Professional, Scientific, and Technical Services | $102,000 | $102,590 | 11 | <$5M | Research |
| Devlan Hospitality LLC | Accommodation and Food Services | $101,100 | $101,780 | 42 | $13.1M | Research |
| Fairview Contractors, Inc. | Construction | $101,000 | $101,688 | 10 | <$5M | Research |
| Fairview Contractors Inc. | Construction | $101,000 | $101,575 | 8 | <$5M | Research |
| Jashoda Llc. | Accommodation and Food Services | $100,152 | $100,865 | 13 | <$5M | Research |
| Litton Landscapes, LLC | Administrative and Support and Waste Management | $100,000 | $100,758 | 8 | <$5M | Research |