| Trihydro Corporation | Professional, Scientific, and Technical Services | $8,376,920 | $8,473,541 | 477 | $58.8M |  Research |
| Mountain West Farm Bureau | Finance and Insurance | $3,803,070 | $3,846,519 | 254 | $130.5M | Research |
| Gem City Bone & Joint, P.c. | Health Care and Social Assistance | $2,070,700 | $2,094,471 | 163 | $51.2M | Research |
| Western Water Consultants, Inc. | Professional, Scientific, and Technical Services | $1,560,170 | $1,569,061 | 104 | $12.8M | Research |
| Western Water Consultants INC | Professional, Scientific, and Technical Services | $1,511,292 | $1,520,360 | 95 | $11.7M | Research |
| Cathedral Home for Children | Health Care and Social Assistance | $1,188,650 | $1,196,010 | 147 | N/A | Research |
| Cathedral Home for Children | Health Care and Social Assistance | $1,083,538 | $1,091,318 | 142 | N/A | Research |
| Ark Industries | Health Care and Social Assistance | $953,850 | $961,534 | 200 | N/A | Research |
| Laramie Gm Auto Center | Retail Trade | $938,700 | $949,678 | 90 | $22.7M | Research |
| Dbjjdm, Enterprises LLC | Educational Services | $924,500 | $929,842 | 69 | $14.5M | Research |
| University of Wyoming Research Corporation | Professional, Scientific, and Technical Services | $788,235 | $795,664 | 38 | N/A | Research |
| Mks Technology INC | Manufacturing | $632,950 | $637,112 | 40 | $10.5M | Research |
| Medicine Bow Technologies INC | Professional, Scientific, and Technical Services | $564,831 | $571,021 | 22 | <$5M | Research |
| Medicine Bow Technologies INC | Professional, Scientific, and Technical Services | $564,830 | $568,590 | 22 | <$5M | Research |
| Schroll Cabinets, Inc. | Manufacturing | $525,203 | $530,002 | 54 | $14.1M | Research |
| Groathouse Construction, Inc. | Construction | $500,000 | $573,764 | 40 | $45.6M | Research |
| Triple a Building Services, Inc. | Construction | $488,769 | $491,956 | 40 | $45.6M | Research |
| Ocean 5 Enterprises LLC | Accommodation and Food Services | $484,377 | $488,199 | 54 | $10.1M | Research |
| First Street Station Inc. | Accommodation and Food Services | $479,780 | $483,014 | 51 | $9.1M | Research |
| Tungsten Parts Wyoming, Inc. | Manufacturing | $470,327 | $473,458 | 70 | $17.1M | Research |
| Care United Medical Center of Laramie, LLC | Health Care and Social Assistance | $433,200 | $436,488 | 95 | $29.8M | Research |
| Wrch - Laramie LLC | Accommodation and Food Services | $403,017 | $407,985 | 55 | $9.8M | Research |
| Wyoming Public Media/university of Wyoming | Information | $364,708 | $366,866 | 35 | N/A | Research |
| Me3, LLC | Retail Trade | $350,000 | $352,839 | 35 | $8.8M | Research |
| Big Horn Roofing INC | Construction | $343,500 | $346,173 | 33 | $10.9M | Research |