| Key Largo Hospitality Land Trust | Accommodation and Food Services | $2,033,300 | $2,055,460 | 255 | $79.7M |  Research |
| Mangrove Marine Holdings | Accommodation and Food Services | $726,761 | $729,429 | 98 | $30.6M | Research |
| Dilly Key Restaurant Holding | Accommodation and Food Services | $709,437 | $640,846 | 77 | $13.7M | Research |
| Immanuel Investments Inc. | Accommodation and Food Services | $697,739 | $704,181 | 75 | $13.3M | Research |
| Key Largo Fisheries INC | Agriculture, Forestry, Fishing and Hunting | $668,500 | $676,039 | 68 | $6.4M | Research |
| Big Chill LLC | Accommodation and Food Services | $571,501 | $577,327 | 115 | $20.4M | Research |
| Dilly Key Restaurant Holding LLC | Accommodation and Food Services | $571,400 | $578,539 | 81 | $14.4M | Research |
| Keys Roofing, Inc. | Construction | $534,847 | $538,759 | 37 | $12.2M | Research |
| Mangrove Marine Holdings | Accommodation and Food Services | $518,000 | $521,903 | 98 | $30.6M | Research |
| Bruce L Boros MD PA | Real Estate and Rental and Leasing | $516,393 | $519,420 | 72 | $10.8M | Research |
| Coral Reef Park Company Inc. | Arts, Entertainment, and Recreation | $514,590 | $519,507 | 32 | <$5M | Research |
| Coral Reef Park Company, Inc. | Arts, Entertainment, and Recreation | $514,589 | $520,535 | 32 | <$5M | Research |
| Eagle Ray Divers LLC | Educational Services | $514,300 | $521,800 | 65 | $8.4M | Research |
| Snappers Key Largo LLC | Accommodation and Food Services | $511,000 | $515,214 | 50 | $8.9M | Research |
| Immanuel Investments, Inc. | Accommodation and Food Services | $498,383 | $502,124 | 90 | $16.0M | Research |
| Riva Motorsports and Marine of the Keys | Retail Trade | $487,956 | $493,364 | 31 | $8.1M | Research |
| Eagle Ray Divers LLC | Educational Services | $477,900 | $481,205 | 72 | $9.4M | Research |
| Big Chill, LLC | Accommodation and Food Services | $440,500 | $444,244 | 66 | $11.7M | Research |
| Jp Logistics USA LLC | Transportation and Warehousing | $400,785 | $0 | 25 | $5.0M | Research |
| T-Shirt City / Sunglass City L.l.c. | Retail Trade | $390,100 | $395,312 | 54 | $14.9M | Research |
| The Medical Center at Ocean Reef INC | Health Care and Social Assistance | $387,526 | $392,219 | 27 | N/A | Research |
| Sebastian (kp) Enterprises, INC | Administrative and Support and Waste Management | $384,500 | $386,910 | 38 | $8.2M | Research |
| Cafe Largo Inc. | Accommodation and Food Services | $382,144 | $384,575 | 57 | $10.1M | Research |
| Snappers Key Largo LLC | Accommodation and Food Services | $366,100 | $368,547 | 75 | $13.3M | Research |
| Coral Reef Tropical Pools, INC | Other Services (except Public Administration) | $365,500 | $367,584 | 38 | $7.4M | Research |