| Deeb Construction and Development Co. | Construction | $537,570 | $543,633 | 59 | $17.9M |  Research |
| Bene's International School of Beauty INC | Educational Services | $455,725 | $458,814 | 35 | $7.4M | Research |
| Ayo and Iken Plc | Professional, Scientific, and Technical Services | $455,320 | $460,417 | 32 | $7.8M | Research |
| Sacred Heart Care, Inc. | Health Care and Social Assistance | $450,000 | $453,088 | 191 | $32.7M | Research |
| Charlie Craig and Associates, LLC | Information | $449,200 | $454,800 | 28 | <$5M | Research |
| Esthers School INC | Educational Services | $437,500 | $442,642 | 99 | N/A | Research |
| Gv New Port Richey, LLC | Health Care and Social Assistance | $436,700 | $442,240 | 79 | $13.4M | Research |
| Commonwealth Capital Corp. | Real Estate and Rental and Leasing | $433,125 | $417,246 | 35 | $15.8M | Research |
| Bene's International School of Beauty INC | Educational Services | $424,875 | $429,041 | 50 | $10.5M | Research |
| Widell Industries INC | Manufacturing | $423,482 | $404,605 | 69 | $16.9M | Research |
| Team Management of Pasco, Inc. | Administrative and Support and Waste Management | $416,000 | $419,617 | 68 | $14.7M | Research |
| Seven Springs Golf and Country Club, Inc. | Arts, Entertainment, and Recreation | $407,900 | $411,163 | 95 | $13.3M | Research |
| Creation Foundation, Inc. | Educational Services | $400,000 | $404,678 | 132 | N/A | Research |
| 3 Season's Lawn & Landscape, Inc. | Administrative and Support and Waste Management | $393,000 | $395,282 | 55 | $11.9M | Research |
| Jacobs Auto Enterprise Inc. | Retail Trade | $390,302 | $392,969 | 48 | $12.1M | Research |
| 1005 Roofing, LLC | Construction | $375,868 | $379,318 | 55 | $18.1M | Research |
| Pasco Kids First, Inc. | Health Care and Social Assistance | $373,628 | $277,227 | 25 | <$5M | Research |
| Excel Medical Imaging, P.l. | Health Care and Social Assistance | $370,617 | $373,016 | 33 | $10.4M | Research |
| Coastal Jaw Surgery of New Port Richey, P.a. | Health Care and Social Assistance | $368,130 | $370,702 | 39 | $12.2M | Research |
| Advocate Education, LLC | Health Care and Social Assistance | $363,500 | $365,623 | 122 | $20.9M | Research |
| Athenian Academy of Technology and the Arts INC | Educational Services | $362,350 | $363,950 | 39 | N/A | Research |
| Collision Center of Pasco County, LLC | Other Services (except Public Administration) | $334,557 | $336,760 | 32 | $6.3M | Research |
| Liberty Land Management Group, Inc. | Administrative and Support and Waste Management | $331,000 | $332,912 | 39 | $8.4M | Research |
| Excel Medical Imaging P.l. | Health Care and Social Assistance | $323,427 | $326,271 | 32 | $10.0M | Research |
| Asl of New Port Richey, Fl, Llc. | Health Care and Social Assistance | $311,000 | $315,518 | 62 | $10.5M | Research |