| Remetronix | Construction | $2,325,600 | $1,715,206 | 126 | $40.2M |  Research |
| Ivox Solutions, LLC | Administrative and Support and Waste Management | $2,074,200 | $2,101,683 | 172 | $32.5M | Research |
| Ivox Solutions, LLC | Administrative and Support and Waste Management | $2,000,000 | $2,024,167 | 102 | $19.3M | Research |
| Port St. Lucie Mgt,llc | Health Care and Social Assistance | $1,626,158 | $1,644,558 | 180 | $30.6M | Research |
| Communities Connected for Kids, Inc. | Health Care and Social Assistance | $1,421,669 | $448,047 | 126 | N/A | Research |
| Gerelco Traffic Controls, INC | Construction | $1,388,900 | $394,736 | 18 | $5.9M | Research |
| Oculus Surgical, INC | Manufacturing | $920,790 | $932,370 | 42 | $11.7M | Research |
| A & G Concrete Pools INC | Construction | $877,902 | $898,777 | 67 | $22.8M | Research |
| Aaron Schamback, D.m.d., P.a. | Health Care and Social Assistance | $832,390 | $841,023 | 31 | $7.2M | Research |
| Cgi St. Lucie, LLC | Arts, Entertainment, and Recreation | $824,010 | $225,067 | 28 | <$5M | Research |
| Coastal Orthopaedics & Sports Medicine Center, Inc. | Health Care and Social Assistance | $782,900 | $787,104 | 65 | $20.4M | Research |
| Brow Arc, Inc. | Other Services (except Public Administration) | $696,600 | $702,173 | 160 | $30.6M | Research |
| Morningside Evangelical Friends Church, Inc. | Other Services (except Public Administration) | $693,000 | $697,879 | 114 | N/A | Research |
| Mark J Powers MD PA | Health Care and Social Assistance | $678,655 | $682,690 | 54 | $16.9M | Research |
| Ross Mixing, Inc. | Manufacturing | $674,800 | $681,604 | 38 | $9.9M | Research |
| Council On Aging of St Lucie Inc-Owner | Health Care and Social Assistance | $592,425 | $596,856 | 52 | N/A | Research |
| E Z Loader Adjustable Boat Trailer Sales Corp | Manufacturing | $577,180 | $581,023 | 63 | $16.5M | Research |
| Sunlight Community Church of Port St. Lucie INC | Other Services (except Public Administration) | $564,580 | $568,767 | 85 | N/A | Research |
| Premier Fabricators LLC | Manufacturing | $561,945 | $566,472 | 69 | $16.9M | Research |
| Usr Holdings LLC | Health Care and Social Assistance | $535,389 | $542,394 | 28 | <$5M | Research |
| Amethyst Recovery Center, LLC | Health Care and Social Assistance | $528,879 | $535,769 | 56 | $10.0M | Research |
| Amethyst Recovery Center LLC | Health Care and Social Assistance | $528,877 | $534,004 | 49 | $8.7M | Research |
| Steinger Iscoe & Greene, PA | Professional, Scientific, and Technical Services | $509,000 | $514,585 | 26 | $6.3M | Research |
| Sunlight Community Church of Port St. Lucie, Inc. | Other Services (except Public Administration) | $508,600 | $511,157 | 77 | N/A | Research |
| 1st Class Pizza INC | Accommodation and Food Services | $440,624 | $443,831 | 109 | $19.4M | Research |