| Middle Flint Area Community Service Board | Health Care and Social Assistance | $1,433,020 | $1,442,414 | 179 | $30.5M |  Research |
| Barksdale and Associates, Inc. | Manufacturing | $1,273,438 | $1,281,601 | 85 | $84.3M | Research |
| Sumter Electric Membership Corporation | Utilities | $1,270,278 | $1,280,892 | 64 | N/A | Research |
| Perry Brothers Oil Company Inc. | Wholesale Trade | $1,235,586 | $1,244,286 | 208 | $53.5M | Research |
| Perry Brothers Oil Co., Inc. | Retail Trade | $955,698 | $962,480 | 186 | $44.5M | Research |
| Leatherbrook Holsteins, LLC | Agriculture, Forestry, Fishing and Hunting | $865,026 | $871,946 | 102 | $16.7M | Research |
| Austin Urethane, LLC | Manufacturing | $678,195 | $681,985 | 74 | $73.4M | Research |
| Pharmacentra, LLC | Professional, Scientific, and Technical Services | $604,966 | $611,926 | 98 | $10.1M | Research |
| Pharmacentra LLC | Administrative and Support and Waste Management | $570,757 | $576,214 | 98 | $18.5M | Research |
| The Southland Academy, Inc. | Educational Services | $507,922 | $511,178 | 81 | N/A | Research |
| Old Biscayne Designs, INC | Manufacturing | $494,200 | $497,016 | 55 | $14.4M | Research |
| Old Biscayne Designs, INC | Manufacturing | $494,200 | $497,788 | 73 | $19.1M | Research |
| Southern Wholesale Glass, Inc. | Manufacturing | $481,426 | $484,130 | 58 | $57.5M | Research |
| Recreation Unlimited, LLC | Manufacturing | $445,960 | $450,847 | 99 | $25.9M | Research |
| Gulf States Cold Storage Co. | Transportation and Warehousing | $434,983 | $437,427 | 55 | $14.0M | Research |
| Gulf States Cold Storage Co. | Transportation and Warehousing | $434,983 | $438,165 | 53 | $13.4M | Research |
| Pecan Grove Dairy, LLC | Agriculture, Forestry, Fishing and Hunting | $434,725 | $437,203 | 52 | $5.3M | Research |
| Regional Eye Center LLP | Health Care and Social Assistance | $414,867 | $419,163 | 56 | $13.1M | Research |
| Golden Gourmet, LLC | Health Care and Social Assistance | $391,360 | $393,805 | 51 | $8.3M | Research |
| Parker's Heating and Air Conditioning, Inc. | Other Services (except Public Administration) | $368,000 | $370,065 | 34 | $7.3M | Research |
| Middle Flint Area Council On Aging, Inc. | Other Services (except Public Administration) | $365,650 | $368,295 | 95 | N/A | Research |
| Clinic Drug Store INC | Retail Trade | $342,462 | $344,475 | 37 | $6.5M | Research |
| Magnolia Packing, Inc. | Transportation and Warehousing | $339,957 | $341,988 | 75 | $5.8M | Research |
| Resolute of Tennessee, Inc. | Manufacturing | $323,443 | $325,507 | 22 | $21.8M | Research |
| Georgia Cold Storage Co | Transportation and Warehousing | $317,387 | $319,195 | 44 | $11.2M | Research |