| Memorial Hospital Association | Health Care and Social Assistance | $2,209,800 | $2,656,143 | 194 | N/A |  Research |
| Professional Swine Employment, LLC | Agriculture, Forestry, Fishing and Hunting | $1,721,295 | $1,740,899 | 175 | $28.6M | Research |
| Professional Swine Management, LLC | Agriculture, Forestry, Fishing and Hunting | $856,100 | $861,688 | 65 | <$5M | Research |
| Carthage Veterinary Service, Ltd | Professional, Scientific, and Technical Services | $825,600 | $831,008 | 65 | $9.1M | Research |
| Carroll Family Farms Partnership | Agriculture, Forestry, Fishing and Hunting | $431,300 | $452,620 | 38 | $6.2M | Research |
| Carson Ford, Inc. | Retail Trade | $271,400 | $273,398 | 20 | $5.0M | Research |
| Carson Ford INC | Retail Trade | $237,500 | $239,855 | 23 | $5.8M | Research |
| Hancock County Senior Services | Other Services (except Public Administration) | $232,700 | $234,167 | 38 | N/A | Research |
| Western Illinois Electric Coop | Utilities | $211,800 | $213,412 | 15 | N/A | Research |
| Wisehart Investments INC | Transportation and Warehousing | $197,879 | $200,061 | 14 | <$5M | Research |
| Turkey Hill Farms LLC | Agriculture, Forestry, Fishing and Hunting | $194,860 | $197,080 | 20 | <$5M | Research |
| Olive Branch Acres LLC | Agriculture, Forestry, Fishing and Hunting | $154,255 | $155,995 | 13 | <$5M | Research |
| A.c. Mccartney, Inc. | Retail Trade | $152,138 | $153,190 | 14 | <$5M | Research |
| Timberline LLC | Agriculture, Forestry, Fishing and Hunting | $143,236 | $144,859 | 16 | <$5M | Research |
| Wisehart Investments Inc. | Transportation and Warehousing | $141,305 | $142,271 | 13 | <$5M | Research |
| Ecs Truckwash LLC | Agriculture, Forestry, Fishing and Hunting | $118,128 | $119,460 | 16 | <$5M | Research |
| Wear Drug INC | Retail Trade | $114,664 | $115,782 | 23 | <$5M | Research |
| Ranrose Farms INC | Agriculture, Forestry, Fishing and Hunting | $109,678 | $11,548 | 4 | <$5M | Research |
| Grand View LLC | Agriculture, Forestry, Fishing and Hunting | $107,495 | $108,728 | 13 | <$5M | Research |
| New Era Sow, LLC | Agriculture, Forestry, Fishing and Hunting | $105,100 | $106,133 | 8 | <$5M | Research |
| Prairie Construction & Contracting LLC | Construction | $104,900 | $105,608 | 14 | <$5M | Research |
| Prairie Construction & Contracting LLC | Construction | $104,717 | $105,554 | 10 | <$5M | Research |
| Jw Medical, Inc. | Retail Trade | $98,600 | $99,742 | 11 | <$5M | Research |
| Soil Service INC | Agriculture, Forestry, Fishing and Hunting | $95,967 | $96,316 | 8 | <$5M | Research |
| Carthage Quality Meats, LLC | Retail Trade | $91,400 | $92,697 | 17 | <$5M | Research |