| Middle Creek Swine, LLC | Agriculture, Forestry, Fishing and Hunting | $83,100 | $84,252 | 21 | <$5M | AI Deep Dive |
| Carthage Innovative Swine Solutions | Professional, Scientific, and Technical Services | $82,400 | $83,210 | 7 | <$5M | AI Deep Dive |
| Bergman Farm Supply, Inc. | Wholesale Trade | $80,700 | $70,132 | 10 | <$5M | AI Deep Dive |
| Neally Brothers, INC | Accommodation and Food Services | $80,600 | $80,994 | 25 | <$5M | AI Deep Dive |
| Advance Physical Therapy of Hancock County, LLC | Health Care and Social Assistance | $73,663 | $74,312 | 5 | <$5M | AI Deep Dive |
| Homestead Lumber Co. | Retail Trade | $70,559 | $71,126 | 11 | <$5M | AI Deep Dive |
| Cokel Welding Shop | Other Services (except Public Administration) | $64,530 | $65,023 | 8 | <$5M | AI Deep Dive |
| Capps Ancelet Icenogle & Wallace | Professional, Scientific, and Technical Services | $60,845 | $61,252 | 7 | <$5M | AI Deep Dive |
| J & R Tire Service, Inc. | Retail Trade | $60,200 | $60,613 | 7 | <$5M | AI Deep Dive |
| Kevin Cook INC | Construction | $56,405 | $56,646 | 9 | $10.3M | AI Deep Dive |
| Western Illinois Mutual Insurance Company | Finance and Insurance | $56,100 | $56,415 | 8 | <$5M | AI Deep Dive |
| Kevin Cook, INC | Construction | $55,055 | $55,720 | 10 | $11.4M | AI Deep Dive |
| Little Timber LLC | Agriculture, Forestry, Fishing and Hunting | $54,800 | $55,427 | 5 | <$5M | AI Deep Dive |
| Always Home Incorporated | Administrative and Support and Waste Management | $52,700 | $53,045 | 20 | <$5M | AI Deep Dive |
| Carthage Livestock, INC | Agriculture, Forestry, Fishing and Hunting | $50,500 | $51,110 | 15 | <$5M | AI Deep Dive |
| Printy Funeral Home Inc. | Other Services (except Public Administration) | $49,800 | $50,486 | 3 | <$5M | AI Deep Dive |
| Jk Pork | Agriculture, Forestry, Fishing and Hunting | $48,592 | $48,772 | 7 | <$5M | AI Deep Dive |
| Kris Dornbush | Finance and Insurance | $48,300 | $48,750 | 4 | <$5M | AI Deep Dive |
| David Fecht | Other Services (except Public Administration) | $45,400 | $45,743 | 6 | <$5M | AI Deep Dive |
| Kirby Construction | Construction | $45,200 | $45,496 | 4 | <$5M | AI Deep Dive |
| Capps, Ancelet, Icenogle & Wallace | Professional, Scientific, and Technical Services | $45,105 | $45,412 | 7 | <$5M | AI Deep Dive |
| Menn's Firestone LLC | Retail Trade | $43,738 | $44,056 | 6 | <$5M | AI Deep Dive |
| Jk Pork | Agriculture, Forestry, Fishing and Hunting | $39,300 | $39,564 | 4 | <$5M | AI Deep Dive |
| Tucker Hartzell and Bryant | Professional, Scientific, and Technical Services | $38,407 | $38,931 | 4 | <$5M | AI Deep Dive |
| Los Charros of Carthage Inc. | Accommodation and Food Services | $38,291 | $38,499 | 7 | <$5M | AI Deep Dive |