| Rush County Memorial Hospital | Health Care and Social Assistance | $827,000 | $735,266 | 91 | N/A | AI Deep Dive |
| Rush County Nursing Home Society | Health Care and Social Assistance | $339,700 | $342,418 | 48 | N/A | AI Deep Dive |
| Miller Trucking, Ltd | Transportation and Warehousing | $300,995 | $302,809 | 22 | <$5M | AI Deep Dive |
| Furniture by Lacrosse LLC | Manufacturing | $298,357 | $300,114 | 50 | $13.1M | AI Deep Dive |
| La Crosse Furniture Co | Manufacturing | $298,300 | $300,115 | 48 | $12.6M | AI Deep Dive |
| Flame Engineering, Inc. | Manufacturing | $261,800 | $263,276 | 29 | $7.6M | AI Deep Dive |
| Skillett & Sons, Inc. | Transportation and Warehousing | $255,000 | $256,516 | 20 | <$5M | AI Deep Dive |
| Morgan Brothers Construction, Inc. | Construction | $133,900 | $135,139 | 17 | $19.4M | AI Deep Dive |
| Rush County Insurance Services, INC | Finance and Insurance | $85,283 | $85,832 | 4 | <$5M | AI Deep Dive |
| Precision Turning, Inc. | Manufacturing | $80,700 | $81,214 | 6 | <$5M | AI Deep Dive |
| Dechant & Gros, Chartered | Professional, Scientific, and Technical Services | $75,250 | $75,749 | 5 | <$5M | AI Deep Dive |
| Lacrosse Livestock Market, INC | Agriculture, Forestry, Fishing and Hunting | $61,700 | $62,170 | 27 | <$5M | AI Deep Dive |
| Schaffer Oil INC | Retail Trade | $47,484 | $47,708 | 11 | <$5M | AI Deep Dive |
| Rush County Pharmacy, LLC | Retail Trade | $45,385 | $45,676 | 4 | <$5M | AI Deep Dive |
| Schaffer Oil, INC | Retail Trade | $42,690 | $43,014 | 12 | <$5M | AI Deep Dive |
| Barry A. Paige, DDS | Health Care and Social Assistance | $40,513 | $40,761 | 4 | <$5M | AI Deep Dive |
| Ryan Georg | Agriculture, Forestry, Fishing and Hunting | $39,142 | $39,309 | 6 | <$5M | AI Deep Dive |
| David a Hein | Mining, Quarrying, and Oil and Gas Extraction | $36,800 | $21,074 | 1 | <$5M | AI Deep Dive |
| Enslinger Lumber Co INC | Retail Trade | $29,410 | $29,630 | 4 | <$5M | AI Deep Dive |
| Enslinger Lumber Co INC | Manufacturing | $29,400 | $29,577 | 3 | <$5M | AI Deep Dive |
| Rush County Grocery, LLC | Retail Trade | $28,125 | $28,347 | 8 | <$5M | AI Deep Dive |
| Bob Reifschneider Trucking | Transportation and Warehousing | $27,257 | $27,444 | 1 | <$5M | AI Deep Dive |
| Robert Reifschneider | Transportation and Warehousing | $27,257 | $27,388 | 1 | <$5M | AI Deep Dive |
| The Rush County News LLC | Information | $25,500 | $25,671 | 4 | <$5M | AI Deep Dive |
| Mark Baus | Agriculture, Forestry, Fishing and Hunting | $25,140 | $25,316 | 2 | <$5M | AI Deep Dive |