| Phillips County Hospital | Health Care and Social Assistance | $1,034,680 | $1,044,176 | 126 | N/A |  Research |
| Prairie Horizon Agri-Energy LLC | Manufacturing | $511,915 | $514,075 | 36 | $35.7M | Research |
| Prairie Horizon Agri-Energy LLC | Manufacturing | $511,750 | $515,381 | 36 | $35.7M | Research |
| Solida Tree Service INC | Administrative and Support and Waste Management | $437,600 | $440,034 | 42 | $9.1M | Research |
| Phillips County Retirement Corporation | Health Care and Social Assistance | $429,217 | $431,722 | 61 | $10.4M | Research |
| Rebel Staffing, LLC | Administrative and Support and Waste Management | $228,930 | $230,322 | 35 | $5.5M | Research |
| Bach Oil Production INC | Mining, Quarrying, and Oil and Gas Extraction | $210,230 | $211,071 | 11 | <$5M | Research |
| Rebel Staffing LLC | Administrative and Support and Waste Management | $187,515 | $188,758 | 28 | <$5M | Research |
| Hospice Service, Inc. | Health Care and Social Assistance | $182,900 | $183,917 | 15 | N/A | Research |
| Coomes, Inc. | Transportation and Warehousing | $151,200 | $152,389 | 20 | <$5M | Research |
| Cliff's Welding Service, INC | Manufacturing | $134,500 | $135,565 | 14 | <$5M | Research |
| Mapes and Miller LLP | Professional, Scientific, and Technical Services | $127,200 | $128,106 | 13 | <$5M | Research |
| B&b Redimix, Inc. | Manufacturing | $111,840 | $112,566 | 15 | $14.9M | Research |
| Midwest Family Health of Phillipsburg, Inc. | Retail Trade | $111,607 | $112,601 | 11 | <$5M | Research |
| Midwest Family Health of Russell, LLC | Retail Trade | $90,100 | $90,902 | 8 | <$5M | Research |
| Matteson Motor INC | Wholesale Trade | $74,780 | $75,102 | 9 | <$5M | Research |
| Witmer Drug Store, Inc. | Retail Trade | $73,100 | $73,687 | 8 | <$5M | Research |
| Sawyer's Incorporated | Retail Trade | $68,300 | $68,938 | 11 | <$5M | Research |
| Midwest Family Health, Inc. | Management of Companies and Enterprises | $68,200 | $68,807 | 5 | <$5M | Research |
| Midwest Family Health of Plainville, LLC | Retail Trade | $66,500 | $67,092 | 6 | <$5M | Research |
| Ronald J Juenemann O.d. P.a. | Health Care and Social Assistance | $60,968 | $61,197 | 11 | <$5M | Research |
| Great Plains Funeral Service INC | Other Services (except Public Administration) | $58,073 | $58,363 | 2 | <$5M | Research |
| Heartland Distribution & Supply LLC | Wholesale Trade | $57,200 | $57,588 | 5 | <$5M | Research |
| Ronald J Juenemann, O.d., P.a. | Health Care and Social Assistance | $54,100 | $54,391 | 10 | <$5M | Research |
| Midwest Family Health of Smith Center, LLC | Retail Trade | $53,200 | $53,674 | 4 | <$5M | Research |