| Great Plains of Cheyenne County INC | Health Care and Social Assistance | $1,316,000 | $1,323,567 | 102 | N/A | AI Deep Dive |
| Robert Yost Enterprises INC | Retail Trade | $516,400 | $520,818 | 51 | $10.5M | AI Deep Dive |
| Cheyenne County Village | Health Care and Social Assistance | $324,150 | $326,320 | 33 | N/A | AI Deep Dive |
| The St Francis Mercantile Equi | Retail Trade | $202,000 | $203,392 | 15 | <$5M | AI Deep Dive |
| Cheyenne Feed Yard, LLC | Agriculture, Forestry, Fishing and Hunting | $97,633 | $98,748 | 13 | <$5M | AI Deep Dive |
| Ross Manufacturing INC | Manufacturing | $89,942 | $90,397 | 14 | <$5M | AI Deep Dive |
| St Francis Feed Yard LLC | Agriculture, Forestry, Fishing and Hunting | $88,900 | $86,459 | 7 | <$5M | AI Deep Dive |
| Republican Valley Veterinary Clinic INC | Professional, Scientific, and Technical Services | $71,895 | $71,490 | 11 | <$5M | AI Deep Dive |
| Frewen Insurance Agency Inc. | Finance and Insurance | $70,367 | $70,779 | 4 | <$5M | AI Deep Dive |
| M John Keller Family Farms INC | Agriculture, Forestry, Fishing and Hunting | $67,778 | $68,198 | 3 | <$5M | AI Deep Dive |
| M. John Keller Family Farms Inc. | Agriculture, Forestry, Fishing and Hunting | $63,678 | $64,015 | 3 | <$5M | AI Deep Dive |
| Wheeler Cooperative Mercantile Equity Union | Agriculture, Forestry, Fishing and Hunting | $61,780 | $62,099 | 4 | <$5M | AI Deep Dive |
| Wheeler Cooperative Mercantile Equity Union | Agriculture, Forestry, Fishing and Hunting | $49,900 | $50,147 | 4 | <$5M | AI Deep Dive |
| Roger Zweygardt | Agriculture, Forestry, Fishing and Hunting | $46,031 | $46,219 | 3 | <$5M | AI Deep Dive |
| Roger Zweygardt | Agriculture, Forestry, Fishing and Hunting | $44,324 | $44,577 | 9 | <$5M | AI Deep Dive |
| Kyle Schultz | Agriculture, Forestry, Fishing and Hunting | $41,053 | $41,342 | 1 | <$5M | AI Deep Dive |
| Callicrate Cattle Co, LLC | Agriculture, Forestry, Fishing and Hunting | $39,970 | $40,229 | 6 | <$5M | AI Deep Dive |
| Grace Flying Service INC | Agriculture, Forestry, Fishing and Hunting | $39,920 | $40,103 | 3 | <$5M | AI Deep Dive |
| Saint Francis Super's INC | Retail Trade | $39,537 | $39,958 | 3 | <$5M | AI Deep Dive |
| Daran T Neitzel | Agriculture, Forestry, Fishing and Hunting | $38,658 | $38,917 | 1 | <$5M | AI Deep Dive |
| Melvin R. Dunn DDS | Health Care and Social Assistance | $38,500 | $38,748 | 4 | <$5M | AI Deep Dive |
| Mike Rogers Farm | Agriculture, Forestry, Fishing and Hunting | $37,510 | $37,689 | 3 | <$5M | AI Deep Dive |
| Timothy Raile | Agriculture, Forestry, Fishing and Hunting | $36,682 | $36,818 | 3 | <$5M | AI Deep Dive |
| Albert Keller Farms Inc. | Agriculture, Forestry, Fishing and Hunting | $36,543 | $36,829 | 5 | <$5M | AI Deep Dive |
| Sunny Crest Farm | Agriculture, Forestry, Fishing and Hunting | $35,100 | $35,311 | 3 | <$5M | AI Deep Dive |