| Franklin Parish Hospital Service District#1 | Health Care and Social Assistance | $2,550,005 | $2,578,055 | 295 | $58.5M |  Research |
| Northeast Louisiana Ambulance Service, LLC | Health Care and Social Assistance | $729,831 | $739,765 | 65 | $15.1M | Research |
| Northeast Louisiana Power Cooperative INC | Utilities | $729,202 | $734,084 | 60 | N/A | Research |
| Northeast Louisiana Power Cooperative, Inc. | Utilities | $711,344 | $714,782 | 58 | N/A | Research |
| Winnsboro Opco, LLC | Health Care and Social Assistance | $477,900 | $483,515 | 142 | $24.2M | Research |
| Sango Buick Gmc, LLC | Retail Trade | $326,320 | $328,169 | 27 | $6.8M | Research |
| White Ford LLC | Management of Companies and Enterprises | $318,228 | $320,022 | 27 | <$5M | Research |
| White Ford LLC | Retail Trade | $318,227 | $320,083 | 27 | $6.8M | Research |
| Colvin Clinic LLC | Health Care and Social Assistance | $301,645 | $303,765 | 29 | $9.1M | Research |
| Sango Buick Gmc, LLC | Retail Trade | $295,102 | $297,192 | 24 | $6.0M | Research |
| Winnsboro Church of the Nazarene, INC | Other Services (except Public Administration) | $284,392 | $284,192 | 50 | N/A | Research |
| Winnsboro Auto Ventures LLC | Retail Trade | $270,200 | $274,043 | 23 | $5.8M | Research |
| Franklin Rubber Resources LLC | Manufacturing | $262,582 | $264,639 | 29 | $28.8M | Research |
| Franklin Rubber Resources LLC | Manufacturing | $243,648 | $245,103 | 36 | $35.7M | Research |
| Home Care Tlc Inc. | Health Care and Social Assistance | $219,508 | $220,630 | 17 | <$5M | Research |
| Home Care Tlc Inc. | Health Care and Social Assistance | $219,507 | $221,050 | 18 | <$5M | Research |
| Franklin Community Services, Inc. | Health Care and Social Assistance | $219,330 | $222,254 | 39 | $6.6M | Research |
| Waller Singer Chevrolet INC | Retail Trade | $212,717 | $214,513 | 22 | $5.5M | Research |
| Waller-Singer Chevrolet, Inc. | Retail Trade | $212,717 | $213,922 | 22 | $5.5M | Research |
| Kiper Hardware & Lumber Corporation | Retail Trade | $182,632 | $183,936 | 23 | <$5M | Research |
| Bethesda Health Services Inc. | Health Care and Social Assistance | $171,882 | $173,458 | 31 | $5.3M | Research |
| Hospice Tlc INC | Health Care and Social Assistance | $171,380 | $172,227 | 15 | <$5M | Research |
| Hospice Tlc INC | Health Care and Social Assistance | $171,380 | $172,584 | 17 | <$5M | Research |
| Martin Brothers Inc. | Manufacturing | $163,858 | $164,723 | 15 | $5.3M | Research |
| Martin Brothers Inc. | Manufacturing | $163,200 | $164,034 | 14 | <$5M | Research |