| The O'connell Comanies, Inc. | Real Estate and Rental and Leasing | $6,952,300 | $7,033,632 | 369 | $55.4M |  Research |
| Holyoke Health Center | Health Care and Social Assistance | $5,368,220 | $4,682,242 | 320 | N/A | Research |
| Universal Plastics Group INC | Manufacturing | $4,263,140 | $4,317,613 | 377 | $373.9M | Research |
| Hazen Paper Company | Manufacturing | $2,339,500 | $2,365,523 | 205 | $203.3M | Research |
| American Environmental, Inc. | Construction | $2,089,000 | $2,116,872 | 143 | $48.7M | Research |
| Westmass Eldercare, Inc. | Health Care and Social Assistance | $2,000,000 | $2,024,822 | 197 | N/A | Research |
| Universal Plastics Group INC | Manufacturing | $2,000,000 | $2,013,808 | 290 | $287.6M | Research |
| Edaron, Inc. | Manufacturing | $1,729,800 | $1,740,035 | 173 | $48.3M | Research |
| Center for School Crisis Intervention and Assessment, Inc. | Educational Services | $1,581,100 | $1,594,572 | 130 | $15.6M | Research |
| Marcotte Ford Sales, Inc. | Retail Trade | $1,440,200 | $1,457,322 | 124 | $31.2M | Research |
| The Log Cabin Banquet and Meeting House INC | Accommodation and Food Services | $1,381,608 | $1,391,778 | 275 | $48.8M | Research |
| Marcotte Ford Sales Inc. | Wholesale Trade | $1,312,365 | $1,321,296 | 109 | $33.4M | Research |
| Western Massachusetts Training Consortium, Inc. | Health Care and Social Assistance | $1,290,739 | $1,298,094 | 282 | N/A | Research |
| Charter Oak Financial INC | Finance and Insurance | $1,181,700 | $1,191,154 | 72 | $37.0M | Research |
| Charter Oak Financial INC | Finance and Insurance | $1,143,020 | $1,151,444 | 71 | $36.5M | Research |
| The Log Cabin Banquet and Meeting House, Inc. | Accommodation and Food Services | $1,011,195 | $1,021,083 | 275 | $48.8M | Research |
| Hampden Paper, Inc. | Manufacturing | $932,500 | $937,836 | 49 | $48.6M | Research |
| Meyers Brothers Kalicka, P.c. | Professional, Scientific, and Technical Services | $921,768 | $932,957 | 59 | $18.8M | Research |
| Holyoke Pediatrics Associates, LLP | Health Care and Social Assistance | $914,300 | $918,897 | 65 | $20.4M | Research |
| Mount Holyoke Management, LLC | Real Estate and Rental and Leasing | $895,700 | $902,318 | 104 | $19.0M | Research |
| Holyoke News Co, INC | Wholesale Trade | $887,700 | $898,109 | 104 | $26.8M | Research |
| School Based Services, INC | Educational Services | $746,000 | $752,254 | 115 | $13.8M | Research |
| Vertitechit, Inc. | Professional, Scientific, and Technical Services | $726,100 | $734,296 | 25 | $5.2M | Research |
| The Dowd Agencies, LLC | Finance and Insurance | $700,742 | $706,463 | 45 | $23.1M | Research |
| Gary Rome Hyundai, Inc. | Retail Trade | $688,700 | $905,794 | 77 | $19.4M | Research |