| Coastal Family Health Center | Public Administration | $2,589,400 | $2,619,692 | 281 | N/A |  Research |
| Biloxi Lodging LLC | Accommodation and Food Services | $2,000,000 | $1,856,686 | 144 | $45.0M | Research |
| Broussard Plumbing, INC | Construction | $1,395,100 | $1,407,255 | 94 | $32.0M | Research |
| Biloxi Lodging, LLC | Accommodation and Food Services | $1,234,077 | $1,788,508 | 144 | $45.0M | Research |
| Swetman Security Services INC | Administrative and Support and Waste Management | $1,164,000 | $1,172,419 | 400 | $58.6M | Research |
| Coastal Industrial Contractors, INC | Construction | $1,148,400 | $1,160,041 | 88 | $30.0M | Research |
| Buddy's Rollco LLC | Real Estate and Rental and Leasing | $1,032,800 | $1,047,486 | 79 | $35.7M | Research |
| Broussard Plumbing, INC | Construction | $802,296 | $809,286 | 94 | $32.0M | Research |
| Biloxi Freezing and Processing Co. | Manufacturing | $732,490 | $737,227 | 104 | $36.7M | Research |
| Medical Analysis LLC | Health Care and Social Assistance | $656,236 | $661,486 | 88 | $27.6M | Research |
| James R. Mcelroy Inc. | Accommodation and Food Services | $648,702 | $651,688 | 106 | $18.8M | Research |
| D.n.p. INC | Construction | $619,047 | $626,768 | 45 | $51.3M | Research |
| Mary Mahoney's Inc. | Accommodation and Food Services | $616,816 | $625,958 | 85 | $15.1M | Research |
| M & M Processing LLC | Agriculture, Forestry, Fishing and Hunting | $599,021 | $604,371 | 76 | $7.2M | Research |
| Shaggy's Biloxi, LLC | Accommodation and Food Services | $592,448 | $601,716 | 37 | $6.6M | Research |
| Aladdin Construction Company, Inc. | Construction | $592,050 | $595,569 | 48 | $54.7M | Research |
| Eley Guild Hardy Architects, PA | Professional, Scientific, and Technical Services | $585,750 | $589,079 | 34 | $10.5M | Research |
| Biloxi Sf LLC | Accommodation and Food Services | $568,124 | $570,885 | 61 | $10.8M | Research |
| Knight Abbey Commercial Printers INC | Manufacturing | $568,050 | $571,932 | 60 | $59.5M | Research |
| Knight-Abbey Commercial Printers | Manufacturing | $568,000 | $573,838 | 63 | $62.5M | Research |
| Eley Guild Hardy Architects PA | Professional, Scientific, and Technical Services | $567,982 | $558,616 | 37 | $11.5M | Research |
| Half Shell Oyster House Biloxi LLC | Accommodation and Food Services | $548,597 | $552,651 | 89 | $15.8M | Research |
| Cable Man Inc. | Construction | $537,965 | $543,448 | 45 | $14.8M | Research |
| Cable Man, Inc. | Construction | $537,900 | $540,936 | 45 | $14.8M | Research |
| Gulf Coast Produce Distributors Inc. | Wholesale Trade | $533,379 | $537,178 | 55 | $14.2M | Research |