| Blue Sky Community Services LLC | Health Care and Social Assistance | $291,200 | $293,968 | 30 | <$5M |  Research |
| B & B Door Company | Manufacturing | $286,000 | $288,312 | 22 | $5.8M | Research |
| Custom Cut Fabrication LLC | Manufacturing | $285,935 | $287,317 | 30 | $7.3M | Research |
| Saxony Lutheran High School | Educational Services | $284,999 | $287,643 | 30 | N/A | Research |
| N & R of Monticello, Inc. | Health Care and Social Assistance | $267,000 | $270,063 | 51 | $8.7M | Research |
| Jackson Machine and Manufacturing in | Manufacturing | $254,200 | $257,660 | 30 | $7.9M | Research |
| Custom Cut Fabrication, LLC | Manufacturing | $249,090 | $250,834 | 34 | $8.3M | Research |
| Eastern Missouri Industries | Construction | $244,269 | $246,176 | 19 | $6.3M | Research |
| Mcdowell South INC | Retail Trade | $241,500 | $242,830 | 31 | $7.8M | Research |
| Gregory Construction INC | Construction | $241,195 | $242,893 | 12 | <$5M | Research |
| Strickland Engineering, Lc | Professional, Scientific, and Technical Services | $224,500 | $227,422 | 15 | <$5M | Research |
| First Auto Credit LLC | Retail Trade | $222,700 | $224,702 | 35 | $8.8M | Research |
| Ceramo Company, INC | Wholesale Trade | $218,873 | $221,535 | 21 | $5.4M | Research |
| Brown & Brockett INC | Retail Trade | $217,085 | $219,111 | 17 | <$5M | Research |
| Jackson Dental, LLC | Health Care and Social Assistance | $209,100 | $210,389 | 18 | <$5M | Research |
| The Villas of Jackson LLC | Health Care and Social Assistance | $208,200 | $260,547 | 38 | $6.5M | Research |
| Translectric INC | Wholesale Trade | $207,774 | $208,952 | 13 | <$5M | Research |
| Perryville Machine Shop, Inc. | Manufacturing | $205,700 | $207,672 | 17 | <$5M | Research |
| Overhead Door Company of Southeast Missouri, Inc. | Construction | $197,217 | $199,080 | 23 | $7.2M | Research |
| Co-Op Service Center Inc. | Wholesale Trade | $191,931 | $194,010 | 16 | <$5M | Research |
| T & W Masonry LLC | Construction | $188,557 | $189,306 | 15 | <$5M | Research |
| Tractors Classic American Grill LLC | Accommodation and Food Services | $186,457 | $187,628 | 107 | $19.0M | Research |
| Perryville Machine Shop INC | Manufacturing | $182,700 | $183,581 | 18 | <$5M | Research |
| Immaculate Conception Church | Other Services (except Public Administration) | $180,300 | $182,128 | 24 | <$5M | Research |
| D & B Equipment Leasing, LLC | Construction | $177,746 | $179,297 | 13 | <$5M | Research |