| Heartland Surgical Specialists LLP | Health Care and Social Assistance | $137,100 | $137,536 | 11 | <$5M |  Research |
| Ridgeway Trucking, L.l.c. | Transportation and Warehousing | $134,539 | $135,490 | 19 | <$5M | Research |
| California C and R INC | Retail Trade | $128,478 | $129,338 | 40 | $10.0M | Research |
| C & R Supermarkets INC | Retail Trade | $128,418 | $110,307 | 47 | $11.7M | Research |
| Nick Maxwells LLC | Accommodation and Food Services | $123,273 | $124,144 | 14 | <$5M | Research |
| Ocampo LLC | Accommodation and Food Services | $122,362 | $122,821 | 29 | $5.1M | Research |
| Pan Cit, INC | Accommodation and Food Services | $121,618 | $122,327 | 33 | $5.9M | Research |
| Woodward Audiology LLC | Health Care and Social Assistance | $120,164 | $120,628 | 10 | <$5M | Research |
| Woodward Audiology | Health Care and Social Assistance | $120,164 | $120,987 | 12 | <$5M | Research |
| Mary Immaculate Catholic Church, Kirksville | Other Services (except Public Administration) | $117,800 | $118,464 | 30 | N/A | Research |
| Hospice 200, INC | Health Care and Social Assistance | $114,692 | $115,264 | 12 | N/A | Research |
| Kirksville Farm & Home Supply, Inc. | Retail Trade | $113,210 | $114,106 | 22 | <$5M | Research |
| Dki, INC | Accommodation and Food Services | $113,127 | $52,607 | 17 | <$5M | Research |
| H P Industries Inc. | Retail Trade | $112,200 | $112,858 | 13 | <$5M | Research |
| Sun Brite Laundry & Linen INC | Other Services (except Public Administration) | $111,757 | $112,590 | 16 | <$5M | Research |
| Century Assisted Living, LLC | Health Care and Social Assistance | $110,405 | $111,251 | 18 | <$5M | Research |
| Century Assisted Living, LLC | Health Care and Social Assistance | $110,403 | $110,956 | 18 | <$5M | Research |
| Weber Bus, Inc. | Transportation and Warehousing | $110,132 | $151,674 | 55 | $21.1M | Research |
| C & R Supermarkets INC | Retail Trade | $109,555 | $129,303 | 39 | $9.7M | Research |
| Exploring America, Inc. | Other Services (except Public Administration) | $109,423 | $110,036 | 14 | <$5M | Research |
| Kirksville Mini Storage INC | Real Estate and Rental and Leasing | $108,602 | $109,015 | 10 | <$5M | Research |
| Rural Advocates for Independent Living, INC | Health Care and Social Assistance | $105,985 | $106,810 | 10 | N/A | Research |
| Rider Drug Inc. | Retail Trade | $104,488 | $105,203 | 16 | <$5M | Research |
| Woody's Tire Auto & Towing L.l.c. | Transportation and Warehousing | $104,000 | $104,236 | 18 | <$5M | Research |
| Sun Brite Laundry and Linen Inc. | Other Services (except Public Administration) | $103,946 | $104,345 | 16 | <$5M | Research |