| Box Butte General Hospital | Health Care and Social Assistance | $3,026,000 | $3,067,860 | 280 | N/A |  Research |
| Western Cooperative Company | Agriculture, Forestry, Fishing and Hunting | $2,656,700 | $2,491,333 | 212 | $10.7M | Research |
| Vsl Alliance LLC | Health Care and Social Assistance | $593,881 | $598,104 | 113 | $19.2M | Research |
| Panhandle Rural Electric Membership Association | Utilities | $540,498 | $544,912 | 26 | N/A | Research |
| Platform Perrin Holdings LLC | Manufacturing | $366,000 | $368,094 | 35 | $9.2M | Research |
| Thompson Seed Potato, Ptr. | Agriculture, Forestry, Fishing and Hunting | $310,516 | $312,215 | 23 | <$5M | Research |
| Peltz Companies, Inc. | Construction | $235,508 | $237,058 | 15 | <$5M | Research |
| Peltz Companies INC | Construction | $207,800 | $208,781 | 10 | <$5M | Research |
| Alliance Tractor & Implement C | Other Services (except Public Administration) | $201,500 | $202,793 | 17 | <$5M | Research |
| Cover Jones Motor Company | Retail Trade | $200,275 | $202,411 | 17 | <$5M | Research |
| Harris Sales Company | Wholesale Trade | $200,000 | $201,972 | 25 | $6.4M | Research |
| Alliance Animal Clinic, P.c. | Professional, Scientific, and Technical Services | $187,565 | $189,354 | 22 | <$5M | Research |
| Chuck Wagon Fine Foods INC | Accommodation and Food Services | $167,320 | $168,775 | 31 | $5.5M | Research |
| Clarus Corporation | Professional, Scientific, and Technical Services | $154,980 | $156,555 | 21 | <$5M | Research |
| Triangle Electric Inc. | Construction | $136,100 | $136,871 | 16 | $5.3M | Research |
| Alliance Family Dental LLC | Health Care and Social Assistance | $132,629 | $133,458 | 13 | <$5M | Research |
| Church of the Holy Rosary | Other Services (except Public Administration) | $125,000 | $125,052 | 29 | N/A | Research |
| Heartland Pointe LLC | Accommodation and Food Services | $123,140 | $123,855 | 12 | <$5M | Research |
| D&d Berg, LLC | Accommodation and Food Services | $121,007 | $122,143 | 35 | $6.2M | Research |
| Immanuel Evangelical Lutheran Church | Other Services (except Public Administration) | $117,649 | $118,459 | 19 | N/A | Research |
| Dr Collis - Horizon West Dental Alliance | Health Care and Social Assistance | $111,302 | $112,162 | 7 | <$5M | Research |
| Western Valley Irrigation, Inc. | Retail Trade | $100,318 | $100,992 | 18 | <$5M | Research |
| K.l. Wood & Co., L.l.c. | Construction | $99,995 | $100,787 | 13 | <$5M | Research |
| Alliance Family Medicine, LLC | Health Care and Social Assistance | $99,588 | $100,528 | 10 | <$5M | Research |
| Todd's Body and Frame Shop LLC | Other Services (except Public Administration) | $98,400 | $98,887 | 7 | <$5M | Research |