| The Community Hospital Association | Health Care and Social Assistance | $4,350,000 | $4,401,233 | 250 | N/A |  Research |
| Kugler Oil Company | Manufacturing | $1,336,300 | $1,343,724 | 110 | $109.1M | Research |
| Red Willow County | Health Care and Social Assistance | $898,858 | $904,277 | 160 | N/A | Research |
| Mccook Clinic, P.c. | Health Care and Social Assistance | $852,000 | $856,781 | 62 | $19.5M | Research |
| Tequilas Restaurants INC | Accommodation and Food Services | $262,826 | $264,154 | 35 | $6.2M | Research |
| Wagner Ford-Mercury, Inc. | Retail Trade | $262,674 | $264,199 | 20 | $5.0M | Research |
| Mnb Insurance Services, Inc. | Finance and Insurance | $258,030 | $259,636 | 14 | $7.2M | Research |
| Southwest Nebraska Physical Therapy, P.c. | Health Care and Social Assistance | $228,200 | $230,038 | 22 | $5.9M | Research |
| Rick Ruggles and Sons, Llc. | Transportation and Warehousing | $226,000 | $228,737 | 12 | <$5M | Research |
| W Design Associates, Inc. | Professional, Scientific, and Technical Services | $223,100 | $224,352 | 12 | <$5M | Research |
| Cappel Sales INC | Wholesale Trade | $212,500 | $213,899 | 15 | <$5M | Research |
| Red Willow Aviation & Spraying, Inc. | Wholesale Trade | $211,400 | $212,935 | 14 | <$5M | Research |
| Wagner Chevrolet Buick Pontiac Cadillac, Inc. | Retail Trade | $211,290 | $212,517 | 14 | <$5M | Research |
| Rams Horn Dairy LLC | Agriculture, Forestry, Fishing and Hunting | $209,500 | $210,687 | 28 | <$5M | Research |
| Deveny Motors LLC | Retail Trade | $198,449 | $200,020 | 22 | $5.5M | Research |
| St. Patrick Catholic Church/school | Other Services (except Public Administration) | $193,018 | $194,106 | 37 | N/A | Research |
| Red Willow Aviation & Spraying INC | Agriculture, Forestry, Fishing and Hunting | $188,278 | $189,491 | 14 | <$5M | Research |
| Tequilas Restaurants INC | Accommodation and Food Services | $187,733 | $188,854 | 31 | $5.5M | Research |
| U-Save Pharmacy 0f Mccook, LLC | Retail Trade | $185,900 | $187,392 | 20 | <$5M | Research |
| Stull Mccook INC | Accommodation and Food Services | $164,263 | $165,353 | 45 | $8.0M | Research |
| Bryan Hauxwell | Agriculture, Forestry, Fishing and Hunting | $154,950 | $156,220 | 47 | $7.7M | Research |
| American Agricultural Laboratory, Inc. | Professional, Scientific, and Technical Services | $151,107 | $152,597 | 13 | <$5M | Research |
| Wellness Partners LLC | Finance and Insurance | $146,899 | $147,851 | 30 | $15.4M | Research |
| Bryan Hauxwell Trucking INC | Transportation and Warehousing | $142,123 | $143,386 | 43 | $6.5M | Research |
| Doak Construction Inc. | Construction | $142,050 | $143,143 | 13 | <$5M | Research |