| Regional West Physicians Clinic | Health Care and Social Assistance | $5,461,500 | $5,524,307 | 293 | N/A |  Research |
| 21st Century Equipment, LLC | Other Services (except Public Administration) | $5,141,500 | $5,205,483 | 360 | $77.4M | Research |
| Panhandle Cooperative Association | Retail Trade | $1,947,200 | $1,969,160 | 250 | $62.4M | Research |
| Floyd's Truck Center, Inc. | Retail Trade | $1,320,200 | $1,328,231 | 103 | $26.9M | Research |
| Scottsbluff Operations LLC | Health Care and Social Assistance | $1,064,000 | $1,075,340 | 198 | $33.7M | Research |
| Ideal Laundry & Cleaners, Inc. | Other Services (except Public Administration) | $888,600 | $939,276 | 137 | $26.2M | Research |
| Scottsbluff Motor Company | Retail Trade | $732,600 | $738,054 | 77 | $19.4M | Research |
| Northfield Retirement Communities, Inc. | Health Care and Social Assistance | $645,120 | $650,711 | 127 | N/A | Research |
| Regional Care, INC | Finance and Insurance | $607,900 | $611,953 | 48 | $21.1M | Research |
| Aulick Manufacturing, Inc. | Manufacturing | $539,100 | $542,724 | 88 | $23.0M | Research |
| Reganis Auto Center, Inc. | Retail Trade | $492,200 | $496,015 | 49 | $12.3M | Research |
| Magnet Solutions, Inc. | Administrative and Support and Waste Management | $462,500 | $465,776 | 35 | $6.6M | Research |
| Oregon Trail Eye Center P.c. | Health Care and Social Assistance | $456,600 | $546,750 | 42 | $7.7M | Research |
| Sunshine Holdings LLC | Construction | $448,909 | $454,665 | 49 | $55.8M | Research |
| Couplamatic Systems, Inc. | Manufacturing | $400,000 | $402,278 | 28 | $27.8M | Research |
| Sunshine Holdings LLC | Construction | $381,947 | $386,834 | 49 | $55.8M | Research |
| Fremont Motor Scottsbluff, INC | Retail Trade | $370,600 | $373,050 | 34 | $8.6M | Research |
| Accelerated Receivable Solutions, Inc. | Administrative and Support and Waste Management | $362,500 | $365,068 | 40 | $7.6M | Research |
| Know How LLC | Retail Trade | $353,200 | $355,594 | 62 | $16.8M | Research |
| Mc Schaff & Associates | Professional, Scientific, and Technical Services | $306,000 | $307,726 | 21 | <$5M | Research |
| Action Communications Inc. | Information | $301,460 | $303,545 | 26 | <$5M | Research |
| Simmons Olsen Law Firm, P.c., L.l.o. | Professional, Scientific, and Technical Services | $300,000 | $302,025 | 20 | <$5M | Research |
| Simmons Olsen Law Firm P.c. L.l.o. | Professional, Scientific, and Technical Services | $300,000 | $301,225 | 19 | <$5M | Research |
| Action Communications Inc. | Information | $292,900 | $294,731 | 27 | <$5M | Research |
| Scottsbluff Family Pancakes Pancakes Inc. | Accommodation and Food Services | $290,102 | $292,657 | 57 | $10.1M | Research |