| Cheyenne County Hospital Association, INC | Health Care and Social Assistance | $5,796,700 | $4,325,110 | 411 | N/A |  Research |
| Dinklage Feed Yard Inc. | Agriculture, Forestry, Fishing and Hunting | $1,151,485 | $1,155,867 | 125 | $20.5M | Research |
| Dinklage Feed Yard, Inc. | Agriculture, Forestry, Fishing and Hunting | $987,500 | $993,315 | 125 | $20.5M | Research |
| Adams Industries, Inc. | Professional, Scientific, and Technical Services | $966,500 | $977,266 | 78 | $8.1M | Research |
| Adams Industries | Transportation and Warehousing | $884,075 | $894,144 | 87 | $22.1M | Research |
| Crossroads Cooperative Association | Wholesale Trade | $552,700 | $555,924 | 36 | $9.3M | Research |
| Agri-Plastics Usa,llc | Manufacturing | $547,420 | $554,469 | 90 | $89.3M | Research |
| Vitalix, Inc. | Manufacturing | $447,700 | $450,921 | 45 | $15.9M | Research |
| Renkoski Vegetation Services LLC | Professional, Scientific, and Technical Services | $311,576 | $316,068 | 26 | $5.2M | Research |
| Panhandle Automotive Group, LLC | Retail Trade | $267,000 | $268,632 | 32 | $8.1M | Research |
| Renkoski Vegetation Services, LLC | Professional, Scientific, and Technical Services | $224,200 | $226,288 | 26 | $5.2M | Research |
| Master Trading, Inc. | Manufacturing | $196,000 | $197,122 | 21 | $5.5M | Research |
| Best Plumbing, Heating & Cooling, LLC | Construction | $189,500 | $190,595 | 27 | $8.5M | Research |
| Cheyenne County Community Center Foundation INC | Arts, Entertainment, and Recreation | $150,500 | $151,393 | 22 | N/A | Research |
| Cheyenne County Community Center Foundation INC | Arts, Entertainment, and Recreation | $148,950 | $149,744 | 23 | N/A | Research |
| Rauner & Associates P.c. | Professional, Scientific, and Technical Services | $148,900 | $149,760 | 9 | <$5M | Research |
| Maddox Motor Company | Retail Trade | $125,000 | $125,746 | 12 | <$5M | Research |
| Hamann Foods Service INC | Accommodation and Food Services | $110,481 | $110,901 | 14 | <$5M | Research |
| Leasa Hlavinka DDS | Health Care and Social Assistance | $102,822 | $98,274 | 7 | <$5M | Research |
| Sauders INC | Other Services (except Public Administration) | $96,750 | $97,352 | 9 | <$5M | Research |
| Sidney Partnership LLC | Accommodation and Food Services | $88,300 | $98,797 | 7 | <$5M | Research |
| The Insurance Store INC | Finance and Insurance | $88,200 | $88,786 | 8 | <$5M | Research |
| Day and Night Plumbing and Heating, LLC | Construction | $85,750 | $86,225 | 8 | <$5M | Research |
| Raj Motel INC | Accommodation and Food Services | $84,835 | $85,380 | 30 | $9.4M | Research |
| Western Drug Co, INC | Retail Trade | $80,200 | $80,769 | 11 | <$5M | Research |