| Jeri N. Wright, P.c. | Professional, Scientific, and Technical Services | $104,500 | $105,276 | 7 | <$5M |  Research |
| Niagara Labmasters, Inc. | Health Care and Social Assistance | $104,000 | $105,029 | 16 | <$5M | Research |
| Llszazu@hotmail.com | Health Care and Social Assistance | $100,627 | $101,336 | 14 | <$5M | Research |
| Robyn Recoon | Professional, Scientific, and Technical Services | $93,400 | $21,083 | 17 | <$5M | Research |
| Dodge Road Learning Center, INC | Health Care and Social Assistance | $89,400 | $90,492 | 15 | <$5M | Research |
| Natural Restorations by Linda J & Co INC | Administrative and Support and Waste Management | $87,645 | $90,250 | 7 | <$5M | Research |
| A J & J of Amherst, INC | Administrative and Support and Waste Management | $86,170 | $87,294 | 12 | <$5M | Research |
| Jeri N. Wright PC | Professional, Scientific, and Technical Services | $85,987 | $86,640 | 10 | <$5M | Research |
| Legend Wealth Management, LLC | Professional, Scientific, and Technical Services | $83,025 | $83,767 | 10 | <$5M | Research |
| Greater Buffalo Gymnastics & Fitness Center LLC | Educational Services | $77,500 | $78,003 | 20 | <$5M | Research |
| Greater Buffalo Gymnastics & Fitness Cen | Educational Services | $72,300 | $78,237 | 37 | <$5M | Research |
| Andruschat Maintenance Services INC | Administrative and Support and Waste Management | $70,637 | $71,070 | 5 | <$5M | Research |
| A.m. & F.m. Inc. | Accommodation and Food Services | $68,169 | $68,507 | 14 | <$5M | Research |
| Sunny's Drive-In INC | Accommodation and Food Services | $67,490 | $67,878 | 68 | $12.1M | Research |
| K&l Refractories, INC | Construction | $67,000 | $67,837 | 9 | <$5M | Research |
| Bogart Landscape Contracting LLC | Construction | $65,137 | $65,633 | 7 | <$5M | Research |
| Northwood Historic Restoration | Manufacturing | $64,510 | $65,256 | 10 | $9.9M | Research |
| Genene Crofut DDS Pllc | Health Care and Social Assistance | $60,545 | $60,789 | 10 | <$5M | Research |
| New Horizons Dental Associates Pllc | Health Care and Social Assistance | $59,707 | $59,995 | 2 | <$5M | Research |
| Ej Militello & Sons Builders and Perma Lawn Landscape | Administrative and Support and Waste Management | $59,517 | $60,018 | 9 | <$5M | Research |
| Crosspoint Dentistry of Amherst Pllc | Wholesale Trade | $58,332 | $58,602 | 8 | <$5M | Research |
| Natural Restorations by Linda J & Co INC | Construction | $58,012 | $75,233 | 9 | <$5M | Research |
| Crosspoint Dentistry Pllc of Amherst | Health Care and Social Assistance | $57,500 | $58,018 | 7 | <$5M | Research |
| 2194 Millers Port Inc. | Retail Trade | $57,000 | $57,428 | 8 | <$5M | Research |
| 2194 Millers Port INC | Retail Trade | $57,000 | $57,590 | 8 | <$5M | Research |