| Ritner Steel, INC | Manufacturing | $537,200 | $543,232 | 47 | $11.5M | AI Deep Dive |
| Cumberland Goodwill Fire Rescue Ems | Health Care and Social Assistance | $518,900 | $452,260 | 41 | N/A | AI Deep Dive |
| Turner Hydraulics, INC | Manufacturing | $506,900 | $511,344 | 39 | $9.5M | AI Deep Dive |
| Tex Visions LLC | Manufacturing | $504,700 | $509,042 | 74 | $73.4M | AI Deep Dive |
| Cdl Labor Management INC | Transportation and Warehousing | $497,390 | $503,966 | 41 | $8.3M | AI Deep Dive |
| Cdl Labor Management Inc. | Transportation and Warehousing | $486,617 | $493,552 | 25 | <$5M | AI Deep Dive |
| Aschenbach Cadillac Buick Gmc of Carlisle LLC | Retail Trade | $458,900 | $464,802 | 58 | $14.6M | AI Deep Dive |
| Gdd Pharmacy Services Inc. | Real Estate and Rental and Leasing | $448,400 | $453,818 | 60 | $9.0M | AI Deep Dive |
| Saint Patrick Parish and School Charitable Trust | Administrative and Support and Waste Management | $432,900 | $437,421 | 63 | N/A | AI Deep Dive |
| Midatlantic Utilities INC | Construction | $423,748 | $427,950 | 29 | <$5M | AI Deep Dive |
| Carlisle Packaging Company INC | Manufacturing | $422,330 | $425,142 | 46 | $45.6M | AI Deep Dive |
| Clouse Transport LLC | Transportation and Warehousing | $394,500 | $396,122 | 64 | $9.7M | AI Deep Dive |
| John's Mobile Repair Service INC | Transportation and Warehousing | $393,900 | $396,325 | 32 | <$5M | AI Deep Dive |
| Tuckey Mechanical Services INC | Construction | $390,400 | $395,491 | 36 | $11.4M | AI Deep Dive |
| Central Pennsylvania Youth Ballet | Arts, Entertainment, and Recreation | $383,612 | $386,446 | 27 | N/A | AI Deep Dive |
| Central Pennsylvania Youth Ballet | Educational Services | $383,612 | $385,349 | 27 | N/A | AI Deep Dive |
| Union Quarries, INC | Mining, Quarrying, and Oil and Gas Extraction | $382,614 | $384,910 | 29 | <$5M | AI Deep Dive |
| M & J Explosives, LLC | Construction | $382,100 | $385,429 | 27 | $10.1M | AI Deep Dive |
| Echo Industrial, Inc. | Manufacturing | $381,900 | $384,870 | 28 | $7.3M | AI Deep Dive |
| Aschenbach Cadillac Buick Gmc of Carlisle | Retail Trade | $379,300 | $465,019 | 45 | $11.3M | AI Deep Dive |
| Covest INC | Retail Trade | $358,700 | $360,842 | 23 | $5.8M | AI Deep Dive |
| Rose Metal Systems, Inc. | Construction | $350,202 | $352,994 | 24 | $5.6M | AI Deep Dive |
| Best Choice Trailers, Inc. | Administrative and Support and Waste Management | $337,200 | $314,518 | 24 | <$5M | AI Deep Dive |
| Cabin Hollow Butcher Shop, Inc. | Manufacturing | $336,347 | $339,333 | 44 | $15.5M | AI Deep Dive |
| Hj Towing & Recovery, Inc. | Transportation and Warehousing | $333,200 | $335,875 | 34 | <$5M | AI Deep Dive |