| Ryder Memorial Hospital Inc. | Health Care and Social Assistance | $3,568,000 | $3,612,204 | 500 | $99.2M |  Research |
| Hospital Menonita Humacao INC | Health Care and Social Assistance | $1,109,000 | $1,119,104 | 208 | N/A | Research |
| Galephar Pharmaceutical Reseach INC | Manufacturing | $1,071,600 | $1,079,488 | 149 | $147.8M | Research |
| Galephar Pharmaceutical Research INC | Professional, Scientific, and Technical Services | $1,043,000 | $1,055,197 | 169 | $35.1M | Research |
| Programa De Educacion Comunal De Entrega Y Servicio, Inc. | Other Services (except Public Administration) | $735,400 | $741,610 | 146 | $27.9M | Research |
| J C Automation, Corp. | Professional, Scientific, and Technical Services | $538,700 | $545,269 | 57 | $11.8M | Research |
| Rivega, LLC | Retail Trade | $524,095 | $530,006 | 167 | $41.7M | Research |
| Hindustan Platinum Pr LLC | Unknown | $443,900 | $447,932 | 47 | N/A | Research |
| Inmobiliaria Y Desarrolladora Pr Vs INC | Accommodation and Food Services | $429,597 | $433,340 | 87 | $27.2M | Research |
| Tile International Corporation | Retail Trade | $416,800 | $421,281 | 81 | $16.7M | Research |
| Mirus Consulting Group Corp | Professional, Scientific, and Technical Services | $342,200 | $345,565 | 32 | <$5M | Research |
| Inmobiliaria Y Desarrolladora Puerto Rico Vs, Inc. | Accommodation and Food Services | $306,854 | $309,595 | 87 | $27.2M | Research |
| Dr Jose A. Nassar & Asociados | Health Care and Social Assistance | $293,700 | $294,948 | 48 | $11.1M | Research |
| Dr. Jose A. Nassar & Asociados | Health Care and Social Assistance | $287,000 | $289,742 | 49 | $15.4M | Research |
| Educational Associates, Inc. | Educational Services | $268,500 | $270,715 | 75 | N/A | Research |
| Educational Associates, Inc. | Educational Services | $265,800 | $268,281 | 75 | N/A | Research |
| The Palmas Academy Inc. | Educational Services | $259,600 | $262,614 | 51 | $6.1M | Research |
| Benitez Group INC | Retail Trade | $257,595 | $259,742 | 33 | $8.3M | Research |
| Mangual Y Menchaca INC | Retail Trade | $257,400 | $259,559 | 70 | $12.2M | Research |
| Palmas Athletic Club Corp | Arts, Entertainment, and Recreation | $256,600 | $258,510 | 66 | $9.2M | Research |
| Benitez Group, INC | Retail Trade | $255,855 | $257,923 | 35 | $8.8M | Research |
| Dial Household Rentals Inc. | Real Estate and Rental and Leasing | $240,634 | $243,201 | 35 | $15.8M | Research |
| Order of St Benedict Monasterio San Anto | Educational Services | $233,200 | $234,547 | 60 | $7.8M | Research |
| Order of St, Benedit Monasterio San Antonio Abad | Unknown | $232,300 | $234,862 | 62 | N/A | Research |
| Persil INC | Accommodation and Food Services | $225,000 | $226,725 | 34 | $6.0M | Research |