| Prime Health Services, Inc. | Health Care and Social Assistance | $193,600 | $195,735 | 117 | $23.2M |  AI Deep Dive |
| A D P Alarmas De Ponce Inc. | Administrative and Support and Waste Management | $191,000 | $193,244 | 48 | $7.0M | AI Deep Dive |
| Academia Serrant Inc. | Educational Services | $188,500 | $190,411 | 68 | $14.3M | AI Deep Dive |
| Colegio San Judas Tadeo | Unknown | $187,000 | $188,704 | 63 | N/A | AI Deep Dive |
| Lk Autos LLC | Retail Trade | $185,555 | $186,911 | 30 | $7.6M | AI Deep Dive |
| Primary Medical Group, C.s.p. | Health Care and Social Assistance | $184,800 | $185,919 | 35 | $11.0M | AI Deep Dive |
| Primary Medical Group, C.s.p. | Health Care and Social Assistance | $183,000 | $184,576 | 49 | $8.7M | AI Deep Dive |
| Gomez Bus Line INC | Transportation and Warehousing | $182,900 | $183,759 | 80 | $30.8M | AI Deep Dive |
| Management Group Inc. | Health Care and Social Assistance | $181,800 | $184,916 | 24 | $7.5M | AI Deep Dive |
| Senorial Automotive Corporation | Retail Trade | $181,400 | $183,844 | 81 | $20.4M | AI Deep Dive |
| Campolor INC | Manufacturing | $180,800 | $182,909 | 61 | $21.5M | AI Deep Dive |
| Servicios De Salud En El Hogar La Providencia, Inc. | Health Care and Social Assistance | $179,600 | $181,940 | 40 | $6.9M | AI Deep Dive |
| Ponce Resorts, Inc. | Accommodation and Food Services | $178,500 | $180,473 | 48 | $15.0M | AI Deep Dive |
| Golden Industrial Laundry INC | Other Services (except Public Administration) | $177,200 | $178,598 | 66 | $12.6M | AI Deep Dive |
| Academia Serrant INC | Educational Services | $175,900 | $177,161 | 68 | $14.3M | AI Deep Dive |
| Security Plus, Inc. | Administrative and Support and Waste Management | $174,900 | $176,702 | 60 | $8.8M | AI Deep Dive |
| Lk Auto LLC | Retail Trade | $172,415 | $174,364 | 36 | $9.1M | AI Deep Dive |
| Ponce Maintenance Corp | Construction | $172,100 | $174,299 | 41 | $46.7M | AI Deep Dive |
| Laboratorio Vascular Clinico Ponce Inc. | Health Care and Social Assistance | $170,800 | $172,807 | 21 | <$5M | AI Deep Dive |
| El Cerrillo LLC | Retail Trade | $168,100 | $169,029 | 40 | $8.3M | AI Deep Dive |
| El Cerrillo LLC | Retail Trade | $168,100 | $169,463 | 35 | $7.2M | AI Deep Dive |
| Hermanos Santiago Cash and Carry INC | Retail Trade | $167,400 | $169,353 | 81 | $20.2M | AI Deep Dive |
| Panaderia Y Reposteria Glenview INC | Manufacturing | $162,300 | $163,648 | 61 | $21.5M | AI Deep Dive |
| Panaderia Y Reposteria Glenview INC | Manufacturing | $162,300 | $163,860 | 63 | $22.2M | AI Deep Dive |
| A Seda Painting INC | Construction | $161,000 | $162,208 | 60 | $15.2M | AI Deep Dive |