| Encanto Restaurants INC | Accommodation and Food Services | $9,727,100 | $9,841,123 | 500 | $88.8M |  Research |
| Wendco of Puerto Rico INC | Accommodation and Food Services | $7,742,000 | $7,833,563 | 500 | $88.8M | Research |
| Suiza Dairy Corporation | Manufacturing | $4,821,000 | $4,874,835 | 500 | $176.5M | Research |
| Grupo Cooperativo Seguros Multiples | Management of Companies and Enterprises | $4,631,400 | $4,684,661 | 473 | $77.7M | Research |
| Bella International & Esteves 30 | Wholesale Trade | $4,433,533 | $4,486,119 | 500 | $153.2M | Research |
| Presbyterian Community Hospital, Inc. | Health Care and Social Assistance | $4,261,305 | $4,308,653 | 500 | N/A | Research |
| Capitol Security Police, Inc. | Administrative and Support and Waste Management | $4,000,777 | $4,044,674 | 500 | $73.2M | Research |
| Physician Hmo INC | Health Care and Social Assistance | $3,882,200 | $3,930,512 | 372 | $116.8M | Research |
| Universidad Politecnica De Puerto Rico Inc. | Educational Services | $3,768,000 | $3,811,855 | 459 | N/A | Research |
| Cchpr Hospitality, LLC | Accommodation and Food Services | $3,500,000 | $3,564,264 | 498 | $155.7M | Research |
| San Jorge Children's Hospital, Inc. | Health Care and Social Assistance | $3,346,900 | $3,342,376 | 500 | $99.2M | Research |
| Restaurants Operators, Inc. | Accommodation and Food Services | $3,284,900 | $3,323,224 | 500 | $88.8M | Research |
| Condado Duo Vanderbilt Spv, LLC | Accommodation and Food Services | $2,950,700 | $3,006,845 | 426 | $133.2M | Research |
| Mangual Office Cleaning Services, Inc. | Administrative and Support and Waste Management | $2,805,802 | $2,837,991 | 500 | $108.3M | Research |
| Mc Connell Valds LLC | Professional, Scientific, and Technical Services | $2,768,900 | $2,797,453 | 143 | $34.7M | Research |
| Marpor Corporation | Accommodation and Food Services | $2,667,900 | $2,699,248 | 500 | $88.8M | Research |
| Condado Duo La Concha Spv, LLC | Accommodation and Food Services | $2,626,300 | $2,667,518 | 435 | $136.0M | Research |
| Management Temporary & Contract Employment Services, Inc. | Administrative and Support and Waste Management | $2,519,245 | $2,551,505 | 500 | $78.7M | Research |
| Bdo Puerto Rico Psc | Professional, Scientific, and Technical Services | $2,484,700 | $2,513,550 | 308 | $98.0M | Research |
| O'neill & Borges, LLC | Professional, Scientific, and Technical Services | $2,483,000 | $2,511,830 | 142 | $34.5M | Research |
| Autogermana INC | Retail Trade | $2,416,000 | $2,444,388 | 220 | $55.4M | Research |
| Edp University of Puerto Rico, Inc. | Educational Services | $2,219,400 | $2,252,938 | 347 | N/A | Research |
| Csa Architects and Engineers LLP | Professional, Scientific, and Technical Services | $2,137,200 | $2,161,897 | 150 | $46.5M | Research |
| Abarca Health LLC | Professional, Scientific, and Technical Services | $2,033,000 | $2,073,434 | 221 | $22.9M | Research |
| Management Temporary & Contract Employment Services Inc. | Administrative and Support and Waste Management | $2,000,000 | $2,018,333 | 300 | $47.2M | Research |